Results 201 to 210 of about 126,550 (315)

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Congenital Nasal Vestibular Stenosis in an 11-Year-Old: Case Report, Surgical Management, and a Proposal for Refined Nomenclature. [PDF]

Am J Case Rep
Guo J, Niu S, Qian Z, Ji K, Zhou H, Lu X, Zhang XF.   +6 more
europepmc   +1 more source

High‐Throughput Mechanical Rupture of Nuclear Envelope and the Intracellular Dynamics of Massive Wound Repair

Advanced Science, EarlyView.
A microfluidic device with monolithically integrated nanostructures enables high‐throughput wounding of the cell membrane and nuclear envelope. The spatial distribution of charged multivesicular body protein 4B (CHMP4B) within the cell is mapped before and after wounding, showing involvement in repair of both the cell membrane and nuclear envelope ...
Apresio K. Fajrial, Leyla Akh, Stephanie E. Schneider, Wei Tan, Corey P. Neu, Xiaoyun Ding   +5 more
wiley   +1 more source

Giant saphenous vein graft aneurysm and associated constrictive pericarditis in a patient with prior CABG. [PDF]

Glob Cardiol Sci Pract
Larson EL, Hapuarachchy B, Aziz H.
europepmc   +1 more source

Systematic Position Mapping of Split CRISPR‐Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification

Advanced Science, EarlyView.
ABSTRACT Amplification‐free Cas12a diagnostics with split crRNA enable rapid and programmable target recognition, yet insufficient understanding of DNA activator architecture prevents predictable control over trans‐cleavage activity and sensitivity. Here we systematically map over 200 split DNA activator configurations by introducing nicks at every ...
Xiaoyan Tang, Zhe Li, Yuning Lu, Miao Ma, Zijian Mo, Jiajun Ke, Xinyu Luan, Tiangang Luan, Junqiu Zhai   +8 more
wiley   +1 more source

Endothelial Cell Stimulator of Interferon Genes Regulates IL-6 Production and Is Required for Pathologic Cardiac Hypertrophy and Contractile Dysfunction in Experimental Heart Failure. [PDF]

Am J Pathol
Sanders E, Kaur K, Wagner N, Emig R, Aronovitz M, Bayer AL, Theall B, Tai A, Martino N, Good ME, Adam AP, Blanton R, Alcaide P.   +12 more
europepmc   +1 more source

DDSurfer: A Weakly‐Supervised Dual‐Stream Deep Learning Framework for Cortical Surface Reconstruction From Diffusion MRI

Advanced Science, EarlyView.
DDSurfer reconstructs cortical surfaces directly from diffusion MRI without requiring T1‐weighted scans. By fusing complementary microstructural features and learning diffeomorphic deformations, it efficiently generates accurate white matter and pial surfaces, improving geometric fidelity and morphometric reliability across datasets for robust surface ...
Chengjin Li, Wei Zhang, Xi Zhu, Yuqian Chen, Nir A. Sochen, Jarrett Rushmore, Carl‐Fredrik Westin, Yogesh Rathi, Lauren J. O'Donnell, Ofer Pasternak, Fan Zhang   +10 more
wiley   +1 more source

Physical inactivity in preclinical Alzheimer's disease: Risk factor, early symptom, or both? [PDF]

Alzheimers Dement (N Y)
Zhao J, Li X, Wu M, Zhang Z.
europepmc   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

Evolution of Endoscopic and Histologic Assessment of Eosinophilic Esophagitis in Europe and Evolution of the Diagnostic Delay: Data From the EUREOS EoE CONNECT Registry. [PDF]

United European Gastroenterol J
Grueso-Navarro E, Dilaghi E, Fernández-Pacheco J, Amorena E, Savarino EV, Blas-Jhon L, Pérez-Martínez I, Granja-Navacerrada A, Guagnozzi D, Martín-Asenjo L, Pellegatta G, Coletta M, García-Suárez C, de la Riva S, de la Peña-Negro L, Betoré E, Krarup AL, Barrio J, Votto M, Bujanda L, Fernández-Fernández S, Naves JE, González-Almeida A, Honrubia-López R, Carrión S, Oliva S, Caño-Cerdán C, Masiques-Mas ML, Espina-Cadena S, González-Cervera J, Casabona-Francés S, Nicolay-Maneru J, Úbeda-Vargas V, Ghisa M, Romo-de Arriba P, Donado C, Benagues A, Martín-Domínguez V, Nantes-Castillejo O, Arias-González L, Maniero D, Moreira-González H, Maray I, Barrio-Torres J, Pérez-Fernández MT, Ostiz-Llanos M, Rodríguez-Alcolado L, Cabrera-Martínez AM, Laserna-Mendieta EJ, Santander C, Lucendo AJ.   +50 more
europepmc   +1 more source