Advanced Science, EarlyView.PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang +10 more
wiley +1 more source
Congenital Nasal Vestibular Stenosis in an 11-Year-Old: Case Report, Surgical Management, and a Proposal for Refined Nomenclature. [PDF]
Am J Case RepGuo J +6 more
europepmc +1 more source
CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors
Advanced Science, EarlyView.Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen +12 more
wiley +1 more source
Validation of Monocular Pupillometry in Healthy Controls and Patients With Autonomic Dysfunction: Pupillary Biomarkers for Autonomic Failure. [PDF]
Eur J NeurolSander L +6 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan +5 more
wiley +1 more source
Joint effects of visual acuity impairment and visual field loss on reading performance: a low-vision simulation in Chinese readers. [PDF]
Eye Vis (Lond)Luo X +7 more
europepmc +1 more source
AI‐Physics‐Experiment Trinity for Integrated Protein Dynamics Modeling
Advanced Science, EarlyView.This review unites experiments, physics‐based simulations, and AI as a synergistic triad for protein dynamics modeling. It highlights integrative strategies, resolves sampling and forcefield bottlenecks, and outlines challenges and future directions for accurate, interpretable conformational ensemble prediction.
Chen Shi +4 more
wiley +1 more source
Fibroblast RUNX1 Induces Maladaptive Post-Myocardial Infarction Remodeling. [PDF]
JACC Basic Transl SciTsai CR, Martin JF.
europepmc +1 more source
FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model
Advanced Science, EarlyView.FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble +9 more
wiley +1 more source
Pulmonary Endothelium: A Driver and Therapeutic Target in Pulmonary Hypertension. [PDF]
JACC Basic Transl SciKovacs-Kasa A, Annex BH.
europepmc +1 more source