Results 11 to 20 of about 1,069,470 (290)

MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts. [PDF]

PLoS ONE, 2013
Downregulation of the muscle-specific microRNA-1 (miR-1) mediates the induction of pathologic cardiac hypertrophy. Dysfunction of the gap junction protein connexin 43 (Cx43), an established miR-1 target, during cardiac hypertrophy leads to ventricular ...
Antonio Curcio, Daniele Torella, Claudio Iaconetti, Eugenia Pasceri, Jolanda Sabatino, Sabato Sorrentino, Salvatore Giampà, Mariella Micieli, Alberto Polimeni, Beverley J Henning, Angelo Leone, Daniele Catalucci, Georgina M Ellison, Gianluigi Condorelli, Ciro Indolfi   +14 more
doaj   +2 more sources

Inhibiting Receptor of Advanced Glycation End Products Attenuates Pressure Overload-Induced Cardiac Dysfunction by Preventing Excessive Autophagy

Frontiers in Physiology, 2018
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy.
Wenbin Gao, Wenbin Gao, Wenbin Gao, Zheng Zhou, Zheng Zhou, Zheng Zhou, Birong Liang, Birong Liang, Birong Liang, Yusheng Huang, Yusheng Huang, Yusheng Huang, Zhongqi Yang, Zhongqi Yang, Zhongqi Yang, Yang Chen, Yang Chen, Lu Zhang, Lu Zhang, Lu Zhang, Cui Yan, Cui Yan, Cui Yan, Jiajia Wang, Jiajia Wang, Jiajia Wang, Lu Lu, Lu Lu, Lu Lu, Zhaorui Wen, Zhaorui Wen, Shaoxiang Xian, Shaoxiang Xian, Shaoxiang Xian, Lingjun Wang, Lingjun Wang, Lingjun Wang   +36 more
doaj   +2 more sources

Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway.

PLoS ONE, 2016
AimsAlthough extracellular-regulated kinases (ERK) are a well-known central mediator in cardiac hypertrophy, no clinically available ERK antagonist has been tested for preventing cardiac hypertrophy.
Chen Li, Zhongxiu Chen, Hao Yang, Fangbo Luo, Lihong Chen, Huawei Cai, Yajiao Li, Guiying You, Dan Long, Shengfu Li, Qiuping Zhang, Li Rao   +11 more
doaj   +2 more sources

The Role of Magnesium in the Management of Cerebral Vasospasm

Neurology Research International, 2013
Subarachnoid hemorrhage (SAH) is characterized by bleeding into the subarachnoid space, often caused by ruptured aneurysm. Aneurysmal rupture occurs in 700,000 individuals per year worldwide, with 40,000 cases taking place in the United States.
Mitchell J. Odom, Scott L. Zuckerman, J Mocco   +2 more
doaj   +2 more sources

A standardized ultrasound approach in neuralgic amyotrophy

Muscle and Nerve, 2022
Neuralgic amyotrophy (NA), also referred to as idiopathic brachial plexitis and Parsonage‐Turner syndrome, is a peripheral nerve disorder characterized by acute severe shoulder pain followed by progressive upper limb weakness and muscle atrophy. While NA
Natalie E Cignetti, Rebecca S Cox, V. Baute, Marissa B McGhee, N. van Alfen, J. Strakowski, A. Boon, J. Norbury, M. Cartwright   +8 more
semanticscholar   +1 more source

Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure

Circulation: Heart Failure, 2020
Supplemental Digital Content is available in the text. Background: Accumulating evidence suggests that the failing heart reprograms fuel metabolism toward increased utilization of ketone bodies and that increasing cardiac ketone delivery ameliorates ...
Salva R. Yurista, T. Matsuura, Herman H. W. Silljé, K. Nijholt, K. McDaid, Swapnil V. Shewale, T. Leone, John C. Newman, E. Verdin, D. V. van Veldhuisen, R. D. de Boer, D. Kelly, B. Westenbrink   +12 more
semanticscholar   +1 more source

Interleukin-4 Induces the Release of Opioid Peptides from M1 Macrophages in Pathological Pain

Journal of Neuroscience, 2021
Interleukin-4 (IL-4) is an anti-inflammatory cytokine, which can be protective in inflammatory and neurologic disorders, and can alleviate pain. Classically, IL-4 diminishes pain by blocking the production of proinflammatory cytokines. Here, we uncovered
D. Labuz, M. Celik, Viola Seitz, H. Machelska   +3 more
semanticscholar   +1 more source

Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload.

Cardiovascular Research, 2021
AIMS Free fatty acid receptor 4 (Ffar4) is a G-protein coupled receptor for endogenous medium/long-chain fatty acids that attenuates metabolic disease and inflammation. However, the function of Ffar4 in the heart is unclear. Given its putative beneficial
K. Murphy, Brian A. Harsch, Chastity L. Healy, Sonal S. Joshi, Shue Huang, Rachel E. Walker, Brandon M. Wagner, Katherine M. Ernste, Wei Huang, R. Block, C. Wright, N. Tintle, B. Jensen, Q. Wells, G. Shearer, T. O’Connell   +15 more
semanticscholar   +1 more source

Endoscopic Balloon Dilation for Crohn’s Disease-Associated Strictures [PDF]

Clinical Endoscopy, 2017
Management of intestinal strictures associated with Crohn’s disease (CD) is clinically challenging despite advanced medical therapy directed toward mucosal healing to positively influence the natural course of CD-associated complications.
Thomas Klag, Jan Wehkamp, Martin Goetz
doaj   +1 more source

IS THERE A PLACE FOR CHOLANGIOSCOPIC EVALUATION OF BILIARY ANASTOMOTIC STRICTURE AFTER DECEASED DONOR LIVER TRANSPLANT? [PDF]

Arquivos de Gastroenterologia, 2020
BACKGROUND Biliary complications remain one of the most important causes of morbidity and graft loss after liver transplant (LT). Endoscopic therapy of biliary complications has proven to be effective over time, leaving surgical treatment restricted to ...
Fernanda Prata MARTINS, Silvia Mansur Reimão SELETI, Mônica Lucia CONTINI, Gustavo Andrade DE PAULO, Angelo Paulo FERRARI   +4 more
doaj   +1 more source