Cisto pericárdico gigante: relato de caso Giant pericardial cyst: case report
Brazilian Journal of Cardiovascular Surgery, 2007 Os cistos pericárdicos são anomalias congênitas incomuns, sendo a maioria assintomática e diagnosticadas incidentalmente na radiografia de tórax. Os cistos gigantes são raros, havendo poucos relatos concernentes à sua história natural, apresentação ...
Vinicius José da Silva Nina +3 more
doaj +1 more source
Crassicauda boopis in a fin whale (Balaenoptera physalus) ship-struck in the eastern North Atlantic Ocean [PDF]
, 2017 On 9 November 2015, a juvenile male fin whale of 11·60 m length was observed on the bulb of a merchant vessel in the Channel Terneuzen – Ghent (The Netherlands – Belgium).
Delobelle, Morgan +6 more
core +3 more sources
Role of coronary artery spasm in symptomatic and silent myocardial ischemia [PDF]
, 1987 The revival of the concept of coronary spasm has stimulated research into coronary artery disease. Observations in patients with variant angina have substantially contributed to the appreciation of painless myocardial ischemia.
Maseri, Attilio
core +1 more source
OBSERVATIONS ON THE PATHOLOGICAL CHANGES FOLLOWING EXPERIMENTAL HYPERTENSION PRODUCED BY CONSTRICTION OF THE RENAL ARTERY [PDF]
Journal of Experimental Medicine, 1938 The clinical histories and pathological findings of six animals dying within a few days following bilateral constriction of the renal arteries have been presented. No explanation for the rise in blood pressure was found. The clinical histories and pathological findings of twelve animals with a sustained hypertension have been considered ...
openaire +3 more sources
Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy [PDF]
, 2014 Exome sequencing revealed a homozygous missense mutation (c.317C>G [p.Arg106Pro]) in POC1B, encoding POC1 centriolar protein B, in three siblings with autosomal-recessive cone dystrophy or cone-rod dystrophy and compound-heterozygous POC1B mutations (c ...
Arts, Heleen H +17 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]
, 2017 Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco +15 more
core +3 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The Impediment of Impotency and the Condition of Male Impotence: A Canonical-Medical Study: Medical Considerations [PDF]
, 1959 To present the problems involved in the matter of male impotence as related to the validity of marriage, the canonical considerations, as prepared by Rev. Paul v.
Harrington, Paul V. +1 more
core +1 more source
TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice [PDF]
, 2017 Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Birnbaumer, Lutz +10 more
core +1 more source