Results 61 to 70 of about 13,489 (314)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Simultaneous Adrenal and Cardiac G-Protein–Coupled Receptor-Gβγ Inhibition Halts Heart Failure Progression [PDF]

, 2014
ObjectivesThe authors propose simultaneous inhibition of Gβγ signaling in the heart and the adrenal gland as a novel therapeutic approach for heart failure (HF).BackgroundElevated sympathetic nervous system activity is a salient characteristic of HF ...
Smrcka, Alan V., Travers, Joshua G., Wegman, Katherine M., Moalem, Jacob, Hammes, Stephen R., Kamal, Fadia A., Mickelsen, Deanne M., Blaxall, Burns C.   +7 more
core   +1 more source

Traumatic arterial thoracic outlet syndrome after multiple rib fractures not including the first rib in Korea: a case report [PDF]

Journal of Trauma and Injury
Arterial thoracic outlet syndrome (TOS) resulting from thoracic trauma is an exceedingly rare condition, typically caused by a fracture of the first rib or clavicle.
Seock Yeol Lee
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts. [PDF]

, 2013
Downregulation of the muscle-specific microRNA-1 (miR-1) mediates the induction of pathologic cardiac hypertrophy. Dysfunction of the gap junction protein connexin 43 (Cx43), an established miR-1 target, during cardiac hypertrophy leads to ventricular ...
Giampà Salvatore, Angelo Leone, D. Torella, S. Sorrentino, Iaconetti C., A. Curcio, B. Henning, S. Giampà, Catalucci, Daniele, Polimeni Alberto, Leone, Angelo, Catalucci Daniele, Alberto Polimeni, Ciro Indolfi, Sorrentino, Sabato, Curcio A., Micieli, Mariella, Sabatino Jolanda, A. Polimeni, Curcio, Antonio, Ellison G. M., Iaconetti Claudio, D. Catalucci, Sorrentino S., Micieli Mariella, Catalucci D., Giampa S., Leone A., Indolfi Ciro, Polimeni A., M. Micieli, Curcio Antonio, Daniele Torella, E. Pasceri, Polimeni, Alberto, Condorelli, Gianluigi, Jolanda Sabatino, Condorelli G., Sorrentino Sabato, Gianluigi Condorelli, Micieli M., Iaconetti, Claudio, Giampà, Salvatore, Indolfi, Ciro, Pasceri Eugenia, Ellison Georgina M., Henning Beverley J., G. Condorelli, Pasceri E., Daniele Catalucci, Eugenia Pasceri, Sabato Sorrentino, Mariella Micieli, Claudio Iaconetti, C. Iaconetti, Torella, Daniele, Henning B. J., Indolfi C., Georgina M Ellison, Torella D., A. Leone, Condorelli Gianluigi, Pasceri, Eugenia, Sabatino, Jolanda, Ellison, Georgina M., Salvatore Giampà, Torella Daniele, Beverley J Henning, C. Indolfi, Antonio Curcio, G. Ellison, Henning, Beverley J, J. Sabatino, Sabatino J., Leone Angelo   +74 more
core   +1 more source

Síndrome do aprisionamento da artéria poplítea: relato de caso Popliteal artery entrapment syndrome: case report

Jornal Vascular Brasileiro, 2011
A síndrome do aprisionamento da artéria poplítea caracteriza-se pela compressão desta artéria sendo a principal causa de claudicação intermitente em jovens.
Marcelo Bettega, Ariane Szeliga, Rafael Pereira Hagemann, Antônio Lacerda Santos Filho, Nelson Mesquita Júnior   +4 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Image_1_Inhibiting Receptor of Advanced Glycation End Products Attenuates Pressure Overload-Induced Cardiac Dysfunction by Preventing Excessive Autophagy.JPEG [PDF]

, 2018
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy.
Cui Yan (3820771), Zhongqi Yang (703895), Jiajia Wang (157207), Zheng Zhou (152309), Yusheng Huang (5780705), Birong Liang (5780702), Wenbin Gao (825538), Lingjun Wang (4516606), Zhaorui Wen (5780708), Yang Chen (9737), Lu Zhang (50563), Lu Lu (392), Shaoxiang Xian (4516615)   +12 more
core   +1 more source