Results 91 to 100 of about 5,766,560 (402)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Validation of the Thai version of the family reported outcome measure (FROM-16)© to assess the impact of disease on the partner or family members of patients with cancer [PDF]

, 2019
© The Author(s). 2019Background: Cancer not only impairs a patient's physical and psychosocial functional behaviour, but also contributes to negative impact on family members' health related quality of life.
Areewan Cheawchanwattana, Aumkhae Sookprasert, B Edwards, CJ Golics, CJ Golics, HF Kaiser, JFTR Hair, JM Ramada-Rodilla, JW Lim, JW Vardiman, KE Covinsky, Kosin Wirasorn, LJ Cronbach, M Koller, M Tavakol, ME Varnum, MM Mukaka, N Friethriksdottir, Nutjaree Pratheepawanit Johns, Pattariya Chantarasap, PM Watcharee Leurmarnkul, R Mahendran, R Mahrer-Imhof, RB Cattell, S Mahatnirunkul, S Wood-Dauphinee, Sam Salek, SH Kim, Srivieng Pairojkul, Suphat Subongkot, W Meecharoen   +30 more
core   +2 more sources

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Practical challenges in data‐driven interpolation: Dealing with noise, enforcing stability, and computing realizations

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley   +1 more source

Modeling the construct validity of the Berlin Intelligence Structure Model

Estudos de Psicologia (Campinas)
The Berlin Intelligence Structure Model is a hierarchical and faceted model which is originally based on an almost representative sample of tasks found in the literature.
Heinz-Martin Süß, André Beauducel
doaj   +1 more source

SensRORing cholesterol to drive protumoral myelopoiesis

Molecular Oncology, EarlyView.
Bleve et al. uncover a cholesterol‐driven immune evasion pathway, where RORγ‐dependent myelopoiesis shapes tumor immunosuppression. Targeting RORγ and PCSK9 emerges as a strategy to boost cancer immunotherapy. Protumoral myelopoiesis is a determinant of immunoevasion and tumor spread in many malignancies.
Sara Gennari, Luigi Nezi, Teresa Manzo
wiley   +1 more source

Testing domains of the healing experiences in all life stressors questionnaire in a cohort of HIV-infected and HIV-uninfected Chicago women

Psychology Research and Behavior Management, 2017
Erin G Mistretta,1,2 Danetta Sloan,1 Karlynn BrintzenhofeSzoc,3 Kathleen M Weber,4 Ann Berger1 1Pain and Palliative Care Service, National Institutes of Health, Bethesda, MD, 2Department of Psychology, Catholic University of America, Washington, DC ...
Mistretta EG, Sloan D, BrintzenhofeSzoc K, Weber KM, Berger A   +4 more
doaj  

Tests employed in the psychometric validation of the Insulin Treatment Appraisal Scale (ITAS) in T2DM patients; a systematic review of the literature

Journal of Patient-Reported Outcomes
Background Psychological Insulin Resistance (PIR) and negative perceptions regarding insulin treatment are noteworthy challenges in T2DM management, which hinder the timely initiation of insulin treatment.
Saba Rasheed, Anees ur Rehman, Zermina Tasleem, Marryam Azeem, Muhammad Fawad Rasool, Arifa Mehreen, Saleh Karamah Al-Tamimi   +6 more
doaj   +1 more source

Hōmai te Waiora ki Ahau: te ara whakamua - towards the establishment of construct validity [PDF]

, 2003
Hōmai te Waiora ki Ahau: te ara whakamua, is about the development of a tool to measure psychological wellbeing among Māori. Why is it relevant? Because a quick look at the June 2002 edition of New Zealand’s Journal of Psychology will show you that
Palmer, Stephanie
core   +1 more source