Results 71 to 80 of about 5,534,746 (396)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Translation and Psychometric Evaluation of the Gujarati Version of Participation Scale for Stroke Patients: A Cross-sectional Study [PDF]

open access: yesJournal of Clinical and Diagnostic Research
Introduction: Social participation is increasingly recognised as fundamental to stroke rehabilitation outcomes and quality of life. However, existing participation measures for stroke often face cultural and linguistic challenges when used with the ...
Surbala Lourembam, Dhruv Dave
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

School Alienation: A Construct Validation Study

open access: yesFrontline Learning Research, 2017
Early identification of school alienation is of great importance for students’ educational outcomes and successful participation in society. This study examined the psychometric characteristics of a newly developed assessment instrument, the School ...
Julia Morinaj   +5 more
doaj   +1 more source

Internal consistency reliability and construct validity of the safety questionnaire for ride-hailing car [PDF]

open access: yes, 2023
Road traffic accidents involving ride-hailing car (RHC) have become more prevalent in Malaysia in recent years. Therefore, the present study aims to develop a reliable and valid questionnaire for assessing the safety performance of RHC in Malaysia. Three
Abd Rahim, Husniyah   +3 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Construct Validity of the Eating Assessment Tool

open access: yesDisability and Rehabilitation, 2017
Purpose: We aimed to evaluate the construct validity of the Eating Assessment Tool (EAT-10) by determining its dimensionality, rating scale integrity, item-person match, precision and relationship with the degree of airway invasion and functional oral ...
Janina Wilmskoetter   +5 more
semanticscholar   +1 more source

Content and construct validity of the Health of the Nation Scale for Children and Adolescents (HoNOSCA) [PDF]

open access: yes, 2009
Research investigating the content and construct validity of the Health of the Nation Outcome Scale for Children and Adolescents (HoNOSCA) is limited. The present investigation firstly explored the content validity of the HoNOSCA in two studies.
de Nooyer, Karen M.
core  

Construct validity analysis.

open access: yes, 2022
Construct validity analysis.
Yuqi Zhu (146909)   +8 more
core   +1 more source

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