Results 131 to 140 of about 9,281,684 (290)

Constructal law & thermoeconomics

, 2016
In spite of evident differences, Constructal Theory and Thermoeconomics (in particular thermoeconomic optimization) have also some similarities. For instance, they both suggest the optimal allocation of two different types of losses: high permeability vs.
Mauro Reini, REINI, MAURO
core   +1 more source

Locomotion rhythm makes power and speed. [PDF]

Sci Rep, 2023
Bejan A, Gunes U, Almahmoud H.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Construction design

, 2021
The Mihouse urban project consists of common areas with buildings with four to five stories formed by groups of apartments. These buildings can be replicated depending on the place, the density requirements and the types of urban blocks. The whole residential condominium would be composed by 30 buildings surrounded by eight parks destined for different
González Zuluaga, Mariana, Muñoz Lombo, Juliana Alexandra, Aguirre, Juan Pablo, Gómez Etayo, Diego Fernando, Holguin Gonzalez, Javier Ernesto, López Castrillón, Yuri Ulianov   +5 more
openaire   +1 more source

Numerical and Geometric Analysis of Side-Wall Inclination Angle Effects on Longitudinal Hat-Stiffeners in Steel Plates

Applied Mechanics
Thin steel plates with stiffeners are widely employed in several branches of engineering, combining mechanical strength with low weight and serving as both structural and cladding components.
Guilherme Garcia Madsen, Mariana Alvarenga Alves, Luiz Alberto Oliveira Rocha, Elizaldo Domingues dos Santos, William Ramires Almeida, Liércio André Isoldi   +5 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Numerical Analysis of Aspect Ratio Effects on the Mechanical Behavior of Perforated Steel Plates

Metals
Thin plates are commonly used in mechanical structures such as ship hulls, offshore platforms, aircraft, automobiles, and bridges. When subjected to in-plane compressive loads, these structures may experience buckling.
Thiago da Silveira, Eduardo Araujo Crestani, Elizaldo Domingues dos Santos, Liércio André Isoldi   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Optimization of constructal design of a microchannel heat sink [PDF]

, 2006
Past studies have shown that a good microchannel design depends on its lower thermal resistance. However, latest theory based on entropy generation minimization (EGM) stated that lower entropy generation rate must also be considered for an optimized ...
Abidin, Ummikalsom
core