Results 121 to 130 of about 9,281,684 (290)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Constructal Design Applied to the Analysis of the Cutout Type and Cutout Shape Influences in the Mechanical Behavior of Thin Steel Plates Subjected to Buckling

, 2015
Thin steel plates - with or without cutouts - are structural components largely used in several engineering applications as buildings, bridges, ships, airplanes and automobiles.
Helbig, Daniel, Isoldi, Liércio André, LORENZINI, Giulio, Santos, Elizaldo Domingues dos, Rocha, Luiz Alberto Oliveira, Real, Mauro de Vasconcellos, Silva, Caio Cesar Cardoso da   +6 more
core  

Computational Model and Constructal Design Applied to Thin Stiffened Plates Subjected to Elastoplastic Buckling Due to Combined Loading Conditions

Applied Sciences
The size of ships has increased considerably in recent decades. This growth impacts the stress magnitude in the bottom hull plates, which constantly suffer from biaxial compression and lateral water pressure, potentially leading to buckling.
Raí Lima Vieira, Guilherme Ribeiro Baumgardt, Elizaldo Domingues dos Santos, Luiz Alberto Oliveira Rocha, Thiago da Silveira, João Paulo Silva Lima, Liércio André Isoldi   +6 more
doaj   +1 more source

Thermodynamics 2.0: Bridging the natural and social sciences. [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Poudel R, McGowan J, Georgiev GY, Haven E, Gunes U, Zhang H.   +5 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Study About Buckling Phenomenon in Perforated Thin Steel Plates Employing Computational Modeling and Constructal Design Method

Latin American Journal of Solids and Structures
Perforated steel thin plates are commonly used in structural engineering. Due to their geometric characteristics, these panels can suffer the undesired buckling phenomenon.
Daniel Helbig, Caio Cesar Cardoso da Silva, Mauro de Vasconcellos Real, Elizaldo Domingues dos Santos, Liércio André Isoldi, Luiz Alberto Oliveira Rocha   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Modelling the behaviour of thermal energy harvesting devices with phase-change materials. [PDF]

Sci Rep, 2021
Kulish V, Hyhlík T, Sláma P.
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source