Results 101 to 110 of about 9,281,684 (290)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Constructal design of mechanisms

, 2010
International audienceThis paper aims at showing how the constructal theory can be applied to the optimization of mechanisms and machine elements. First of all, the concept of mechanism skeleton needs to be introduced.
Marcelin, Jean-Luc
core  

Numerical simulation and constructal design method applied to perforated composite material plates submited to bending [PDF]

, 2015
Neste trabalho foi realizado um estudo numérico em placas com perfurações elípticas centralizadas, de material isotrópico e compósito, submetidas à flexão provocada por um carregamento transversal uniformemente distribuído, considerando ainda diferentes ...
Isoldi, Liércio André, Silva, Caio César Cardoso da, Troian, Sandro Pieta, Santos, Elizaldo Domingues dos, Rocha, Luiz Alberto Oliveira, Real, Mauro de Vasconcellos   +5 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Constructal design of salt-gradient solar pond fields

, 2016
WOS:000380022100010International audienceSalt-gradient solar ponds (SGSPs) are water bodies that capture and accumulate large amounts of solar energy. The design of an SGSP field has never been analyzed in terms of studying the optimal number of solar ...
Amigo, Jose, González, Daniel I., Amigo Álvarez, José Manuel, Gonzalez, Daniel, Bejan, Adrian, Suárez, F, Suarez, Francisco, Lorente, Sylvie, Lorente, S, Suárez Poch, Francisco Ignacio, Amigo, J, González, D, Bejan, A   +12 more
core   +1 more source

Analysis of the Design of Cavities with Isothermal Blocks under Mixed Convection [PDF]

Journal of Applied and Computational Mechanics
Using the constructal design method (CDM), this study aimed to evaluate how the convective heat transfer in a lid‑driven cavity, with an isothermal block (IB) inside, is affected by the cavity aspect ratio (AR).
Rafael Borahel, Flávia Zinani, Liércio Isoldi, Elizaldo dos Santos, Luiz Rocha   +4 more
doaj   +1 more source

Constructal Optimizations of Line-to-Line Vascular Channels with Turbulent Convection Heat Transfer. [PDF]

Entropy (Basel), 2022
Lin D, Xie Z, Nan G, Jiang P, Ge Y.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Constructal Design of Elliptical Cylinders with Heat Generating for Entropy Generation Minimization. [PDF]

Entropy (Basel), 2020
Wang R, Xie Z, Yin Y, Chen L.
europepmc   +1 more source