Results 81 to 90 of about 370 (252)

An assessment of branching asymmetry of the tracheobronchial tree. [PDF]

Sci Rep, 2022
Miguel AF.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Evolution in Magmatic Conduits: A Constructal Law Analysis of Stochastic Basaltic and Felsic Lava Dynamics

Fluids
This study probabilistically assesses magma ascent by modeling dike propagation as a fully coupled fluid-flow, thermo-mechanical problem, explicitly accounting for the stochastic heterogeneity of the crustal host rock.
Antonio F. Miguel, Vinícius R. Pepe, Luiz A. O. Rocha   +2 more
doaj   +1 more source

Constructal Design of an Arrow-Shaped High Thermal Conductivity Channel in a Square Heat Generation Body. [PDF]

Entropy (Basel), 2020
Zhang F, Feng H, Chen L, You J, Xie Z.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Constructal Optimization of Rectangular Microchannel Heat Sink with Porous Medium for Entropy Generation Minimization. [PDF]

Entropy (Basel), 2021
Li W, Xie Z, Xi K, Xia S, Ge Y.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Computational Model and Constructal Design Applied to Thin Stiffened Plates Subjected to Elastoplastic Buckling Due to Combined Loading Conditions

Applied Sciences
The size of ships has increased considerably in recent decades. This growth impacts the stress magnitude in the bottom hull plates, which constantly suffer from biaxial compression and lateral water pressure, potentially leading to buckling.
Raí Lima Vieira, Guilherme Ribeiro Baumgardt, Elizaldo Domingues dos Santos, Luiz Alberto Oliveira Rocha, Thiago da Silveira, João Paulo Silva Lima, Liércio André Isoldi   +6 more
doaj   +1 more source

Thermodynamics 2.0: Bridging the natural and social sciences. [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Poudel R, McGowan J, Georgiev GY, Haven E, Gunes U, Zhang H.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source