Results 61 to 70 of about 2,621 (293)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Constructal vascularized structures
Open Engineering, 2015 Smart features such as self-healing and selfcooling require bathing the entire volume with a coolant or/and healing agent. Bathing the entire volume is an example of point to area (or volume) flows.
Cetkin Erdal
doaj +1 more source
Design of an innovative off road hybrid vehicle by energy efficiency criteria [PDF]
, 2016 The environmental impact of road transport is significant because it is a major user of energy and the major user of the world's petroleum that is extracted every year.
Pascoa, Jose +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Constructive Methods of Program Design [PDF]
, 1976 Correct programs cannot be obtained by attempts to test or to prove incorrect programs: the correctness of a program should be assured by the design procedure used to build it.
openaire +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Simultaneous Extrema in the Entropy Production for Steady-State Fluid Flow in Parallel Pipes
, 2010 Steady-state flow of an incompressible fluid in parallel pipes can simultaneously satisfy two contradictory extremum principles in the entropy production, depending on the flow conditions.
Andresen +37 more
core +1 more source
A Preliminary Exergy Analysis of the EU DEMO Fusion Reactor [PDF]
, 2019 Purpose of the present study is the exergy analysis of EU DEMO pulsed fusion power plant considering the Primary Heat Transfer Systems, the Intermediate Heat Transfer System (IHTS) including the Energy Storage System (ESS) as a first option to ensure the
Caruso, Gianfranco +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source