Results 61 to 70 of about 9,281,684 (290)
Optimization of Airships with Constructal Design for Efficiency Method
, 2013 It is possible to define a novel optimization method, which aims to overcome the traditional Multidisciplinary Design Optimization. It aims to improve Constructal design method to optimize complex systems such as vehicles. The proposed method is based
Michele Trancossi +5 more
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CONDUCTIVE PATHWAYS CONSTRUCTION USING GENETIC ALGORITHM AND CONSTRUCTAL DESIGN [PDF]
, 2019 In this work, Constructal Design and Genetic Algorithms are used to construct high conductivity paths connected to a heat sink and inserted in a square plate of low conductivity material with internal heat generation.
Souza, J. A. +2 more
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Constructal design of an arterial bypass graft [PDF]
, 2020 Arterial bypass grafts tend to fail after some years due to intimal hyperplasia—an abnormal proliferation of smooth muscle cells that leads to stenosis and graft occlusion.
Rafael F. Dutra +3 more
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Thermal optimization of circular bodies submitted to an intense heat flux using constructal design
Vetor, 2010 The present work studies the optimization of a circular body with an intense heat flux by Constructal Design. The problem concerns the minimization of the global thermal resistance of a three-dimensional structure submitted to an intense uniform heat ...
Leandro Cavalheiro Vergara +2 more
doaj +4 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Architecture After Irreversibility
BuildingsArchitecture has often represented itself through permanence, stability, and formal autonomy while materially existing through irreversible exchanges, dissipation, aging, maintenance, and transformation.
Lazaros Mavromatidis
doaj +1 more source
Constructal vascularized structures
Open Engineering, 2015 Smart features such as self-healing and selfcooling require bathing the entire volume with a coolant or/and healing agent. Bathing the entire volume is an example of point to area (or volume) flows.
Cetkin Erdal
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Otimização Geométrica de Cavidades Complexas Empregando Constructal Design [PDF]
, 2011 Na presente pesquisa, inicialmente foi realizada uma revisão bibliográfica dos temas que circundam a Teoria Constructal e Constructal Design, e também suas aplicações na natureza e na engenharia. Posteriormente, foi feito o estudo do estado da arte sobre
Garcia, Fernanda Link
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