Results 51 to 60 of about 9,281,684 (290)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Constructive Methods of Program Design [PDF]
, 1976 Correct programs cannot be obtained by attempts to test or to prove incorrect programs: the correctness of a program should be assured by the design procedure used to build it.
openaire +2 more sources
Constructal design of solid state fermentation bioreactors [PDF]
, 2009 Constructal Design is applied to geometric optimization of an insulated wall bioreactor. The optimization of the bioreactor geometry allows that it to operate, below a certain temperature limit, without external cooling equipment.
Souza, Jeferson Avila +3 more
core +1 more source
Journal of Marine Science and Engineering, 2023 Studies regarding renewable energy sources have gained attention over recent years. One example is wave energy converters, which harvest energy from sea waves using different operational principles such as oscillating water columns, oscillating bodies ...
Andréia S. de Barros +7 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Constructal Law: Optimization as Design Evolution
, 2015 Copyright © 2015 by ASME. Here, I review the physics meaning of optimization, knowledge and design evolution, and why these concepts and human activities are profoundly useful for human life.
Bejan, A
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Constructal theory of pattern formation [PDF]
Hydrology and Earth System Sciences, 2007 This review article shows that the occurrence of macroscopic flow configuration is a universal natural phenomenon that can be explained and predicted on the basis of a principle of physics (the constructal law): "For a flow system to persist in time
A. Bejan
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source