Results 71 to 80 of about 373 (250)
Geometric optimization of bodies submitted to an intense heat flux using bifurcated channel nets
Vetor, 2010 The present work studies the geometric optimization of a body submitted to intense heat flux. The body to be optimized is refrigerated by a ducts system whose circulating fluid will remove the heat.
Claus de Rosso Bolzan +3 more
doaj +4 more sources
Vascular structures for smart features self-cooling and self-healing
Journal of Thermal Engineering, 2017 Here we show how smart features of self-cooling and self-healing can be gained to mechanical systems with embedded vascular structures. Vascular structures mimic the circulatory system of animals.
E. Cetkin
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Constructal Optimizations of Line-to-Line Vascular Channels with Turbulent Convection Heat Transfer. [PDF]
Entropy (Basel), 2022 Lin D, Xie Z, Nan G, Jiang P, Ge Y.
europepmc +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Analysis of the Design of Cavities with Isothermal Blocks under Mixed Convection [PDF]
Journal of Applied and Computational MechanicsUsing the constructal design method (CDM), this study aimed to evaluate how the convective heat transfer in a lid‑driven cavity, with an isothermal block (IB) inside, is affected by the cavity aspect ratio (AR).
Rafael Borahel +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Constructal Design of Elliptical Cylinders with Heat Generating for Entropy Generation Minimization. [PDF]
Entropy (Basel), 2020 Wang R, Xie Z, Yin Y, Chen L.
europepmc +1 more source