Results 91 to 100 of about 2,621 (293)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Ardeth, 2018 This visual essay diagrams a global design construction network that connects architects to migrant construction workers in a direct line. A hypothetical stadium construction site lies in the center; one side maps the movement of a steel truss from design to fabrication to a building site; the other side charts the path of migrant workers as they ...
Kadambari Baxi +5 more
openaire +3 more sources
Branching in fluidic networks with permeable walls: an extension of Hess-Murray’s law [PDF]
, 2017 The branching of fluidic networks becomes a subject of great interest due to its importance in understanding the behavior of branching networks in biology (cardiovascular and bronchial systems, river basins, the structure of plants and trees, etc..), as ...
Miguel, A. F. +2 more
core
A design rule for constant depth microfluidic networks for power-law fluids [PDF]
, 2015 A biomimetic design rule is proposed for generating bifurcating microfluidic channel networks of rectangular cross section for power-law and Newtonian fluids.
Barber, Robert W. +3 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
“Recent Advances in Energy Research” [PDF]
, 2008 The worldwide scarcity of fossil fuels regarding primary energy demand together with growing environmental concerns have raised new challenges to the world economy, and led to changes in the energy paradigm.
Miguel, A. F., Reis, A. Heitor
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Geometric optimization of bodies submitted to an intense heat flux using bifurcated channel nets
Vetor, 2010 The present work studies the geometric optimization of a body submitted to intense heat flux. The body to be optimized is refrigerated by a ducts system whose circulating fluid will remove the heat.
Claus de Rosso Bolzan +3 more
doaj +4 more sources
Otimização de design do duto ramificado em forma de T com escoamento de fluido newtoniano e paredes impermeáveis [PDF]
, 2018 Este artigo apresenta os resultados de escoamentos em dutos em forma de “T”. O problema consiste em encontrar as resistências ao escoamento em estruturas tridimensionais (3D) cujos sistemas têm diferentes relações homotética entre tamanhos (diâmetros e ...
Miguel, A. F. +3 more
core