Results 91 to 100 of about 370 (252)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Study About Buckling Phenomenon in Perforated Thin Steel Plates Employing Computational Modeling and Constructal Design Method

Latin American Journal of Solids and Structures
Perforated steel thin plates are commonly used in structural engineering. Due to their geometric characteristics, these panels can suffer the undesired buckling phenomenon.
Daniel Helbig, Caio Cesar Cardoso da Silva, Mauro de Vasconcellos Real, Elizaldo Domingues dos Santos, Liércio André Isoldi, Luiz Alberto Oliveira Rocha   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Modelling the behaviour of thermal energy harvesting devices with phase-change materials. [PDF]

Sci Rep, 2021
Kulish V, Hyhlík T, Sláma P.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Locomotion rhythm makes power and speed. [PDF]

Sci Rep, 2023
Bejan A, Gunes U, Almahmoud H.
europepmc   +1 more source

Construction design

, 2021
The Mihouse urban project consists of common areas with buildings with four to five stories formed by groups of apartments. These buildings can be replicated depending on the place, the density requirements and the types of urban blocks. The whole residential condominium would be composed by 30 buildings surrounded by eight parks destined for different
González Zuluaga, Mariana, Muñoz Lombo, Juliana Alexandra, Aguirre, Juan Pablo, Gómez Etayo, Diego Fernando, Holguin Gonzalez, Javier Ernesto, López Castrillón, Yuri Ulianov   +5 more
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Numerical and Geometric Analysis of Side-Wall Inclination Angle Effects on Longitudinal Hat-Stiffeners in Steel Plates

Applied Mechanics
Thin steel plates with stiffeners are widely employed in several branches of engineering, combining mechanical strength with low weight and serving as both structural and cladding components.
Guilherme Garcia Madsen, Mariana Alvarenga Alves, Luiz Alberto Oliveira Rocha, Elizaldo Domingues dos Santos, William Ramires Almeida, Liércio André Isoldi   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source