Results 41 to 50 of about 4,674,321 (263)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Cognitive spaces: Expanding participation framework by looking at signed language interpreters’ discourse and conceptual blending

Translation and Interpreting : the International Journal of Translation and Interpreting Research, 2014
We know from previous research (Wadenjso, 1998; Metzger, 1999; Roy, 2000) that interpreters are active participants within the interpreting event. We know that interpreters interact with the participants, and discourse by negotiating turn-taking, and ...
Julie White Armstrong
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Sustained circulation of Aedes albopictus-derived novel almendraviruses in the urban parks

Biosafety and Health
The Rhabdoviridae family comprises a diverse range of negative-sense single-stranded ribonucleic acid (RNA) viruses, including significant human and mammalian viruses transmitted by various arthropod species.
Xi Zhang, Chengyu Liu, Yang Han, Junying She, Wanqi Wu, Lili Wang, Jingdong Song, George F. Gao, Ziqian Xu, Hao Liang, Jun Liu   +10 more
doaj   +1 more source

3D supersymmetric nonlinear multiple D0-brane action and 4D counterpart of multiple M-wave system

Journal of High Energy Physics, 2022
Found is the complete nonlinear action of multiple D0-brane system (mD0) in three dimensional type II superspace which is invariant under rigid D = 3 N $$ \mathcal{N} $$ = 2 spacetime supersymmetry and under local worldline supersymmetry generalizing the
Igor Bandos, Unai D. M. Sarraga
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Object, problem, or subject?: A child with a disability as found in reports of professionals

Scandinavian Journal of Disability Research, 2009
This study examined the representations of one Finnish child with disabilities as constructed in reports written by professionals. The professional action models which appeared in the discourse of the reports were also explored. The theoretical framework
Tanja Vehkakoski
doaj   +1 more source

Rethinking constructed action [PDF]

, 2015
We aim to demonstrate the importance of defining linguistic phenomena by using constructed action or CA (i.e. a stretch of discourse that represents one role or combination of roles depicting actions, utterances, thought, attitudes and/or feelings of one
Sevcikova, Z, Smith, S, Cormier, KA
core