Results 31 to 40 of about 286,896 (265)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Elastic Local Buckling and Width-to-Thickness Limits of I-Beams Incorporating Flange–Web Interactions

Buildings
The local buckling of I-section beams is investigated with the flange–web interactions taken into account. Using numerical results employing the finite element method and a semi-analytical method, the flange–web interactions of I-sections and their ...
Lei Zhang, Qianjing Zhang, Genshu Tong, Qunhong Zhu   +3 more
doaj   +1 more source

Dynamics of apartment building renovation investment costs based on Estonian reovation grant scheme

Acta Polytechnica CTU Proceedings, 2022
While energy prices have increased substantially recently, we also observe that renovation prices have increased twofold wihtin last decade. This could seriously affect the motivation to invest in building renovations because of negative yield and in ...
Grete Miller, Lauri Lihtmaa, Targo Kalamees   +2 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Enhancing Onshore Wind Tower Foundations: A Comprehensive Automated Design Approach

CivilEng
The realm of green energy is in constant flux, drawing considerable attention from stakeholders dedicated to minimizing environmental impact, reducing costs, and developing structures that align with stringent standards.
Emmanouil Vougioukas, Athanasios Stamos, Charikleia Pappa, Nikos D. Lagaros   +3 more
doaj   +1 more source

Engineer’s estimate reliability and statistical characteristics of bids

Cogent Engineering, 2016
The objective of this report is to provide a methodology for examining bids and evaluating the performance of engineer’s estimates in capturing the true cost of projects.
Fariborz M. Tehrani
doaj   +1 more source

Multiobjective optimization model for scheduling of construction projects under extreme weather

Journal of Civil Engineering and Management, 2016
Extreme weather significantly impacts construction schedules and costs and can be a source of schedule de­lays and budget overruns. A multi-objective optimization model, presented herein for the scheduling of construction projects under extreme weather ...
Ahmed B. Senouci, Saleh A. Mubarak
doaj   +1 more source