Results 71 to 80 of about 2,702,482 (307)
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Embodied Energy and Lifecycle Costs: Questioning (Mis)conceptions about Underground Construction
Buildings, 2019 In the construction community, underground construction is perceived as being significantly more costly and more energy-consuming than comparable surface construction.
Michael Robert Doyle +2 more
doaj +1 more source
Railway construction cost estimation [PDF]
, 2014 196 σ.Σκοπός της εργασίας αυτής είναι η εκτίμηση τους κόστους κατασκευής μιας σύγχρονης σιδηροδρομικής γραμμής καθώς και των λοιπών εγκαταστάσεων που την αποτελούν. Για το σκοπό αυτό προσδιορίζονται και παρουσιάζονται αναλυτικά τα κατασκευαστικά στοιχεία
Deligiannis, Lampros K. +1 more
core +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Probabilistic sensitivity of the cost of earth moving to the variation of operating conditions
Dyna, 2019 The construction comprises a wide spectrum of variables that need to be analyzed to carry out an adequate project planning to generate profit and to comply with the project technical specifications.
Estefanny Zapata-Montenegro +1 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
The Influence of Vertical Ground Motion on the Design of Common R/C Frames
Applied SciencesIn this article, the response of reinforced concrete frames concurrently subjected to both horizontal and vertical seismic motions is assessed. The article is not limited to the variation in response quantities but aims to identify which specific design ...
Grigorios Manoukas, Vasilios Tsiggelis
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
BuildingsGovernment building projects are particularly complex due to their scale and number of end users, which makes construction prices time-consuming and prone to error.
Kongkoon Tochaiwat, Anuwat Budda
doaj +1 more source
Space construction system analysis. Part 2: Cost and programmatics [PDF]
Cost and programmatic elements of the space construction systems analysis study are discussed. The programmatic aspects of the ETVP program define a comprehensive plan for the development of a space platform, the construction system, and the space ...
Cooper, W., Vonflue, F. W.
core +1 more source