Results 51 to 60 of about 4,844,251 (306)

Construction costs of tunnel form buildings

open access: yesGrađevinar, 2013
A residential building with a lateral load resisting system, adopted as a reference example, is considered in the paper. The system is made of shear walls realized using the tunnel form technology. The building is modelled for a varying number of floors,
Zeynep Yeşim İlerisoy   +1 more
doaj   +1 more source

COST ANALYSIS IN CONSTRUCTION OF UNDERGROUND MINING STRUCTURES AND OPPORTUNITIES FOR THEIR REDUCTION

open access: yesRudarsko-geološko-naftni Zbornik, 2015
The construction of underground mining facilities is of essential importance to the exploitation of mineral resources. Confirmation of this is the fact that the construction costs of main facilities occupy 40-60% of the underlying investments in the main
Nikolinka Doneva   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Public policy implications of construction innovation research [PDF]

open access: yes, 2006
This report undertakes an exploratory analysis of Construction Innovation research projects\ud in order to answer the question “What are the public policy implications of Construction\ud Innovation research?

core  

Is Construction Industry Still Performing Worse Than Other Industries? [PDF]

open access: yes, 2022
Research Questions: Is the construction industry improving performance in Finland? Is construction industry performing worse than other industries? Why is the industry scoring high on customer satisfaction, even if it scores low in many other cross ...
Seppänen, Olli, Elfving, Jan A.
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Principii de bază privind metodologia costurilor pe ciclul de viaţă al construcţiilor la nivel european [PDF]

open access: yesUrbanism. Arhitectura. Constructii, 2011
Making life-cycle cost methodology is an acknowledgment of the need for Europe-wide methodology for life cycle buildings costs. The aim of this study is to provide a methodological framework for the universal application of lifetime costs in the ...
Silviu Lambrache
doaj  

A primer in public policy for the construction industry [PDF]

open access: yes, 2005
The purpose of this document is to introduce non-specialists to the discipline and practice of public policy, particularly in relation to the construction sector in Australia. In order to do this, a brief overview of Australia’s government structure, and

core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

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