Results 121 to 130 of about 5,286,845 (378)

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Network Engineering for Complex Belief Networks [PDF]

arXiv, 2013
Like any large system development effort, the construction of a complex belief network model requires systems engineering to manage the design and construction process. We propose a rapid prototyping approach to network engineering. We describe criteria for identifying network modules and the use of "stubs" to represent not-yet-constructed modules.
arxiv  

Leveraging digital tools to advance mathematics competencies among construction students

Cogent Education
This study investigated the impact of integrating design-technological activities on developing mathematical competencies among construction engineering students. A mixed methods approach compared curriculum delivery with and without digital tools across
Elmira Saparbayeva, Marzhan Abdualiyeva, Yerlan Torebek, Nurlibay Madiyarov, Abay Tursynbayev   +4 more
doaj   +1 more source

Case study of engineering-geological researches for linear constructions building

Известия высших учебных заведений: Геология и разведка, 2015
Features of carrying out of engineering-geological researches for building of linear constructions during updating of normative documents: Construction Norms and Regulations 11-02-96. «Engineering researches for construction.
D. N. Gorobtsov, M. E. Nikulina
doaj   +1 more source

Evolutionary Design of Engineering Constructions [PDF]

Latin American Journal of Solids and Structures, 2018
Abstract The basic information required to utilize one of possible computation tools/algorithms (mainly the evolution strategy) to solve a wide class of real practical engineering optimization problems is presented and discussed in the present paper. The effectiveness of the considered method is demonstrated by the possibility of the use of different ...
openaire   +3 more sources

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

The efficiency of simple Quantum Engine Stirling and Ericsson cycle [PDF]

arXiv, 2020
The quantum engine cycle serves as an analogous representation of the macroscopic nature of heat engines and the quantum regime of thermal devices composed of a single element. In this work, we follow the formalism of a quantum engine proposed by Bender et al.
arxiv  

Optimizing Construction Project Plan Management Using Parameter-Adaptive Improved Genetic Algorithm

Tehnički Vjesnik
This study proposes an optimization method for construction project plan management using a parameter-adaptive improved genetic algorithm (IGA) combined with differential evolution (DE).
Tianya Jia
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source