Results 141 to 150 of about 2,280,486 (356)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
International Journal of Adaptive Control and Signal Processing, EarlyView., 2023 Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley +1 more source
RWU Holds Steel “Topping-Off” Ceremony for Engineering, Computing & Construction Management Labs [PDF]
, 2018 Roger Williams University on Monday held a steel “topping-off” ceremony, marking completion of the steel framework for a laboratories building for RWU’s School of Engineering, Computing and Construction ...
Fitzpatrick, Edward
core +1 more source
Construction of Parflux Mark II sediment trap : engineering report [PDF]
, 1979 Susumu Honjo, John F. Connell
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Data‐driven performance metrics for neural network learning
International Journal of Adaptive Control and Signal Processing, EarlyView., 2023 Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri +2 more
wiley +1 more source
Engineering, construction, and operations in space [PDF]
The century-old Mond process for carbonyl extraction of metals from ore shows great promise as an efficient low energy scheme for producing high-purity Fe, Ni, Cr, Mn, and Co from lunar or asteroidal feedstocks.
Johnson, Stewart W., Wetzel, John P.
core +1 more source
Requirements for software engineering languages [PDF]
, 1985 This paper analyzes the concepts of software construction embodied in the Draco system. The analysis relates specific mechanisms in Draco to particular software engineering (SE) principles and suggests future research needed to extend the approach.
Freeman, Peter, Staa, Arndt von
core +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Technology Strategy for Re-engineering Design and Construction [PDF]
, 1999 Automation technology can provide construction firms with a number of competitive advantages. Technology strategy guides a firm's approach to all technology, including automation.
Hampson, Keith, Tatum, C
core +1 more source