Results 91 to 100 of about 355,983 (296)

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Explaining pretrained language models' understanding of linguistic structures using construction grammar. [PDF]

Front Artif Intell, 2023
Weissweiler L, Hofmann V, Köksal A, Schütze H.   +3 more
europepmc   +1 more source

Co-phonology vs. Indexed constraint theory: a case study of Perak dialect partial reduplication [PDF]

, 2012
This paper presents co-phonologies and indexed constraint theory developed within Optimality theory (Prince and Smolensky, 1993) to account for partial reduplication in Perak dialect of Malay.
Syed Jaafar, Sharifah Raihan
core  

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Construction grammar - eine Grammatik für die Interaktion? [PDF]

, 2014
Der Beitrag erkundet die Eignung der Construction Grammar als Rahmentheorie für eine Grammatik der gesprochenen Sprache. Ausgangspunkt der Construction Grammar sind zwei, gerade für gesprochene Sprache sehr häufig zutreffende Beobachtungen: Phrasen- und ...
Deppermann, Arnulf
core  

Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education

Advanced Science, EarlyView.
We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua, Anira Escrichs, Yonatan Sanz Perl, Morten L. Kringelbach, Adele Diamond, Solange Denervaud, Gustavo Deco   +6 more
wiley   +1 more source

A Digital Analysis of the “L”-Shaped Tujia Dwellings in Southeast Chongqing Based on Shape Grammar

Buildings
The Tujia ethnic group is one of the major ethnic groups in China, with a long history and abundant cultural heritage. As a distinctive architectural style, Tujia dwellings have evolved over thousands of years, developing a wealth of construction ...
Quan Wen, Yuqi Zhao, Xianwen Huang, Gang Wang   +3 more
doaj   +1 more source

Highly Robust Sn‐Based MAX Anodes Constructed via Ti6C Octahedral Outer Immobilization and A‐Layer Fe Inner Anchoring for Long‐Life Lithium‐Ion Batteries

Advanced Science, EarlyView.
How can Sn‐based anodes achieve high capacity and long‐life cycling? This work unlocks the potential anode structure by confining Sn in the A layer of MAX phase with Ti6C octahedra as outer immobilization and Fe as inner anchors. The introduction of Fe dramatically strengthens the Ti–Sn bond to enhance structural integrity, modulate interfacial ...
Yu‐ang Lei, Yuchen Guo, Linkai He, Yi Tang, Junhui Zou, Yangyang Xie, Xiaodie Xuan, Zhao Bi, Yu Wang, Ting Liu, Yunqing Kang, Taotao Ai, Yusuke Yamauchi, Chenhui Yang   +13 more
wiley   +1 more source

Alternating predicates in Icelandic and German: a sign-based construction grammar account [PDF]

, 2014
A long-standing divide between Icelandic and German in the literature takes for granted that there are non-nominative subjects in Icelandic, while corresponding arguments in German have been analyzed as objects (Zaenen, Maling & Thráinsson 1985 ...
Barddal, Johanna, Dewey, Tonya Kim, Eythorsson, Thorhallur   +2 more
core  

Correct-by-Construction Approach for Self-Evolvable Robots

, 2017
The paper presents a new formal way of modeling and designing reconfigurable robots, in which case the robots are allowed to reconfigure not only structurally but also functionally.
Chen, Gang, Kong, Zhaodan
core   +1 more source