Results 71 to 80 of about 12,733 (256)
Advanced Science, EarlyView.Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg +18 more
wiley +1 more source
Conversation, Construction Grammar, and cognition [PDF]
Language and Cognition, 2015 abstractRecent developments in grammatical theory seem to invite an integration of grammar and interaction; nevertheless, there are reservations on both sides. While some of these reservations can be traced to misconceptions, others are deeply rooted in the theoretical premises of each approach.
openaire +1 more source
Advanced Science, EarlyView.A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li +14 more
wiley +1 more source
Explaining the Ditransitive Person-Role Constraint: A usage-based approach
Constructions, 2004 In this paper, I propose a frequency-based explanation of the Ditransitive Person-Role Constraint, a cross-linguistic generalization that can be formulated as follows: “Combinations of bound pronouns with the roles Recipient and Theme are disfavored if ...
Martin Haspelmath
doaj
Inferential Processes in English and the Question whether English has Modal Particles
Open Linguistics, 2018 In this paper, we ask whether English pragmatic markers may evoke similar inferential processes in discourse as German modal particles, studying alright/all right, already and then in more detail. Moreover, we investigate whether specific formal features
Fischer Kerstin, Heide Maiken
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Advanced Science, EarlyView.Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan +7 more
wiley +1 more source
Towards a construction grammar account of the distributive PO in Polish
Cognitive Studies | Études cognitives, 2015 Towards a construction grammar account of the distributive PO in Polish Polish distributive constructions involving the form po are well known for their syntactic and semantic idiosyncrasy.
Adam Przepiórkowski
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Advanced Science, EarlyView.This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun +14 more
wiley +1 more source
From sign to construction: the Saussurean legacy and the constructionist approaches of grammar
Gragoatá, 2017 The importance of Ferdinand de Saussure’s propositions, presented in the Course in General Linguistics (CLG), to the establishment of the basis of so-called Modern Linguistics is a consensus among linguists.
Priscilla Mouta Marques +2 more
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Linking in fluid construction grammars
, 2005 One of the key problems in any language processing system is to establish an adequate syntax/semantics interface, and one of the major requirements of such an interface is that partial meanings contributed by individual words are properly linked with each other based on grammatical constructions.
Steels, Luc +2 more
openaire +2 more sources