Results 101 to 110 of about 7,695,805 (356)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Experimental and theoretical study on flexural performance of lightweight sandwich panels using FRP connectors

Case Studies in Construction Materials
Prefabricated concrete sandwich panels are crucial components in the construction of prefabricated buildings, providing essential functions such as load-bearing capacity, thermal insulation, and fire resistance.
Nengming CHENG, Juntian TANG, Peng FENG, Zhihao HAO, Yaolin ZHANG, Mingyuan CHANG   +5 more
doaj   +1 more source

Text Mining Applications in the Construction Industry: Current Status, Research Gaps, and Prospects [PDF]

, 2022
Na Xu, Xueqing Zhou, Chaoran Guo, Bai Xiao, Fei Wei, Yuting Hu   +5 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Barriers to Adopting Lean Methodology in the Portuguese Construction Industry [PDF]

, 2023
Manuel Pedrosa, Amílcar Arantes, Carlos Oliveira Cruz   +2 more
openalex   +1 more source

Trade credit in the UK construction industry: an empirical analysis of construction contractor financial positioning and performance [PDF]

, 2013
Research commissioned by the Department for Business, Innovation & Skills (BIS) to inform analysis for the ‘Industrial Strategy for Construction’. It explores the availability of trade credit for UK construction firms and how they rely upon it to support
Ive, G, Murray, A
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Comprehensive evaluation of low-temperature properties of PPA/CR/SBS composite modified asphalt binder and its mixtures

Results in Engineering
Asphalt pavement in cold regions often suffer from serious cracking issues, which will greatly shorten its service life. Composite modification employing polyphosphoric acid (PPA), crumb rubber (CR), and styrene-butadiene-styrene block copolymer (SBS ...
Fucheng Guo, Ning Li, Songbai Lin, Bo Li, Zhenzheng Liu, Yongning Wang, Sheng Guo, Jing Zhao, Wenzhou Li   +8 more
doaj   +1 more source

The impact of training and development on career advancement of professional women in the UK construction industry [PDF]

The redressing the gender imbalance in the UK construction industry has been emphasised on numerous occasions and many researchers have identified that women can contribute in an immense way towards the construction industry development.
Amaratunga, Dilanthi, Fernando, G.
core