Results 121 to 130 of about 2,012,270 (353)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Exploring Perceptions toward Emotional Intelligence in Chilean Construction Using a Qualitative Approach

Buildings
This study aims to analyze the perceptions of construction experts in the Chilean construction industry regarding emotional intelligence. This exploratory and qualitative study is based on data collected through semi-structured interviews with ...
Pedro Páez, Felipe Araya, Luis Arturo Salazar, Zulay Giménez, Omar Sánchez, Leonardo Sierra-Varela, Briguitte Neculman   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Research and Application of Track Misalignment APM Detection Technology

Chengshi guidao jiaotong yanjiu
Objective In order to solve the problems of low efficiency and poor precision of traditional APM (automated people mover system), it is necessary to study the APM technology for track misalignment detection. Method The line laser sensor is used to obtain
TENG Xingquan
doaj   +1 more source

Are we catering to the construction industry KM requirements?: A literature synthesis [PDF]

The concept of Knowledge Management is now familiar to the construction industry and various attempts are being made for the effective management of knowledge in the industry.
Amaratunga, Dilanthi, Haigh, Richard, Pathirage, C. P.   +2 more
core  

Leadership capability of team leaders in construction industry [PDF]

, 2013
This research was conducted to identify the important leadership capabilities for Malaysia construction industry team leaders. This research used exploratory sequential mix-method research design which is qualitative followed by quantitative research
Wan Muda, Wan Hanim Nadrah
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Performance evaluation and optimal dosage determination of slow release salt storage asphalt mixtures using fuzzy analysis

Scientific Reports
Ice and snow reduce the road surface coefficient of friction, leading to economic losses and jeopardizing driving safety. Salt-storage asphalt pavements often fail to extend pavement life effectively.
Yingke Si, Bo Li, Yongpeng Zhao
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Ti-C and CFs Work Together to Enhance the Comprehensive Tribological Properties of PTFE-Based Composites for the Manufacture of Wave Glider Power Shafts

Lubricants
Wave gliders’ power system shafts face complex conditions. To enhance their operational stability, it is crucial to study PTFE, a polymer material that could replace traditional metals.
Angang Yan, Xingju Yao, Yuan Wei, Qianjian Guo, Yulong Wang, Wuqiang Tang, Xian Xu   +6 more
doaj   +1 more source