Results 41 to 50 of about 314,143 (308)

Engineering economics feasibility analysis of the Takisung Bridge construction package in South Kalimantan Province [PDF]

E3S Web of Conferences
The development of transportation infrastructure, particularly bridges, plays a strategic role in enhancing regional connectivity, accelerating economic growth, and supporting the tourism sector.
Farah Diba Iftitah Theriqa, Rona Puspita Gaby Septia, Kurniawan Budi   +2 more
doaj   +1 more source

Quality and safety in the palestinian construction industry [PDF]

, 2009
Construction industry is one of the largest and most important industries in Palestine. Quality and safety in the industry still suffers from ignorance and lack of supervision and accident rate on construction projects is very high. The objective of this
Choudhry, Rafiq M., Choudhry, R, Abu Alqumboz, Moheeb, Abualqumboz, M, Enshassi, Adnan, Choudhry, Rafiq M, Choudhry, Rafiq, Abualqumboz, Moheeb, Enshassi, A   +8 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Experimental study on bending resistance of joints of large-diameter double-layer-reinforced pipe piles

Yantu gongcheng xuebao
The failure of welded joint of the traditional lateral force pipe piles due to insufficient bending capacity has become a key problem affecting its safety and use.
QI Yuliang 1, 3, TANG Mengxiong 2, HUANG Keke 1, 3, LIANG Weijian 1
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Selective power: A joint planning and operation framework for phased vehicle-to-grid deployment

International Journal of Electrical Power & Energy Systems
Large-scale deployment of Vehicle-to-Grid (V2G) technology is widely recognized as a key enabler for integrating electric-vehicle (EV) fleets into future power systems, yet the prohibitive upfront cost of bi-directional infrastructure, the uncertain ...
Renge Li, Jimin Zeng, Zichen Shen, Huan Chen, Kai Sun, Yongxiang Liu, Wentao Wang   +6 more
doaj   +1 more source

Safety effectiveness indicators (SEI's): measuring construction industry safety performance [PDF]

, 2008
The current application of Positive Perfromance Indicators (PPI's) in the construction industry largely measures numbers of disparate safety activities. Generally they are seen by industry as not providing generalizable indicators of safety effectiveness
Biggs, Herbert C., Dingsdag, Donald P., Dingsdag, Donald P. (R7591), Cipolla, Dean, Cipolla, Dean J.   +4 more
core