Results 51 to 60 of about 314,143 (308)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Extreme combination of wind effects and analysis of wind load characteristics for low-rise buildings

Journal of Asian Architecture and Building Engineering
Based on transcendental probability theory, the probability density functions of two non-Gaussian scalar sums of wind effects are derived from the relationship between the probability density of the sum of random variables and the joint probability ...
Haiwei Guan, Yuji Tian, Yuliang Qi, Weihu Chen   +3 more
doaj   +1 more source

Adoption in the construction industry

, 2006
This report draws together the key findings from six case studies on the subject of ebusiness\ud Adoption in Construction conducted in Australia by the University of Newcastle\ud (UON) and Royal Melbourne Institute of Technology (RMIT) from 2005 through ...

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Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

BENEFITS DERIVED BY DISTRICT ASSEMBLIES FROM THEIR PROJECT CONSULTANTS

Journal of Construction Project Management and Innovation, 2013
Many of the problems in construction at the local level can be traced to consultants who supervise projects on behalf of local government agencies. Consultants therefore need to be evaluated regularly to ensure that they are delivering the expected ...
J Ayarkwa, B.K. Baiden, D. Osei-Asibey, C.B.S Sabah   +3 more
doaj   +1 more source

A primer in public policy for the construction industry

, 2005
The purpose of this document is to introduce non-specialists to the discipline and practice of public policy, particularly in relation to the construction sector in Australia. In order to do this, a brief overview of Australia’s government structure, and

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Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Micro- structure and rheological properties of graphene oxide rubber asphalt

Nanotechnology Reviews, 2019
Compared with traditional materials, nanomaterial has rich and excellent performance due to the size advantages. If nanotechnology is combined with pavement materials, it is foreseeable that it will have a profound impact on the development of the road ...
Lin Mei, Wang Zhao Li, Yang Ping Wen, Li Ping   +3 more
doaj   +1 more source

The state of the art in e-business: A case study from the Chinese construction industry

, 2012
In the 21st century, e-business is seen as the new frontier. Currently e-business has been widely used in other industry and to some extent in global construction market, particularly in developed countries, such as UK, EU and USA.
Zhou, Lei, Perera, Srinath (R18622), Ru, Xudong, Perera, Srinath, Udeaja, Chika   +4 more
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Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source