Results 61 to 70 of about 5,734,746 (248)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The impact of training and development on career advancement of professional women in the UK construction industry [PDF]
The redressing the gender imbalance in the UK construction industry has been emphasised on numerous occasions and many researchers have identified that women can contribute in an immense way towards the construction industry development.
Fernando, G., Amaratunga, Dilanthi
core +3 more sources
Construction planning workbench [PDF]
, 2004 This report is an attempt to present the current state of product and process modelling in the building industry in general, and in construction planning and scheduling in particular.
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Selective power: A joint planning and operation framework for phased vehicle-to-grid deployment
International Journal of Electrical Power & Energy SystemsLarge-scale deployment of Vehicle-to-Grid (V2G) technology is widely recognized as a key enabler for integrating electric-vehicle (EV) fleets into future power systems, yet the prohibitive upfront cost of bi-directional infrastructure, the uncertain ...
Renge Li +6 more
doaj +1 more source
Brite phase 1 report to industry : innovate – now [PDF]
, 2005 Trying to innovate or wanting to? Making a start is the most difficult step on any journey. Whether trying to innovate for the first time, or seeking improvements on current performance, organisations are confronted with a plethora of options. Innovate ―
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Extreme combination of wind effects and analysis of wind load characteristics for low-rise buildings
Journal of Asian Architecture and Building EngineeringBased on transcendental probability theory, the probability density functions of two non-Gaussian scalar sums of wind effects are derived from the relationship between the probability density of the sum of random variables and the joint probability ...
Haiwei Guan +3 more
doaj +1 more source
Safety effectiveness indicators (SEI's): measuring construction industry safety performance [PDF]
, 2008 The current application of Positive Perfromance Indicators (PPI's) in the construction industry largely measures numbers of disparate safety activities. Generally they are seen by industry as not providing generalizable indicators of safety effectiveness
Biggs, Herbert C. +4 more
core +1 more source
Quality and safety in the palestinian construction industry [PDF]
, 2009 Construction industry is one of the largest and most important industries in Palestine. Quality and safety in the industry still suffers from ignorance and lack of supervision and accident rate on construction projects is very high. The objective of this
Choudhry, Rafiq M. +8 more
core +1 more source