Results 61 to 70 of about 2,007,738 (306)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Extreme combination of wind effects and analysis of wind load characteristics for low-rise buildings

Journal of Asian Architecture and Building Engineering
Based on transcendental probability theory, the probability density functions of two non-Gaussian scalar sums of wind effects are derived from the relationship between the probability density of the sum of random variables and the joint probability ...
Haiwei Guan, Yuji Tian, Yuliang Qi, Weihu Chen   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

BENEFITS DERIVED BY DISTRICT ASSEMBLIES FROM THEIR PROJECT CONSULTANTS

Journal of Construction Project Management and Innovation, 2013
Many of the problems in construction at the local level can be traced to consultants who supervise projects on behalf of local government agencies. Consultants therefore need to be evaluated regularly to ensure that they are delivering the expected ...
J Ayarkwa, B.K. Baiden, D. Osei-Asibey, C.B.S Sabah   +3 more
doaj   +1 more source

Holistic Learning: A workforce development paradigm [PDF]

, 2015
The development of workforce knowledge, skills and attitudes are widely acknowledged in extant literature as being pivotal levers to deliver process improvement and efficiency.
Adjaie John, Godfaurd, Ene, Gloria Unoma, Goulding, Jack Steven, Pour Rahimian Leilabadi, Farzad   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Micro- structure and rheological properties of graphene oxide rubber asphalt

Nanotechnology Reviews, 2019
Compared with traditional materials, nanomaterial has rich and excellent performance due to the size advantages. If nanotechnology is combined with pavement materials, it is foreseeable that it will have a profound impact on the development of the road ...
Lin Mei, Wang Zhao Li, Yang Ping Wen, Li Ping   +3 more
doaj   +1 more source

Construction industry: Priority Sector Report

, 2019
The construction industry plays a strategic role in the EU economy, accounting for 9% of gross domestic product (GDP) and 18 million direct jobs. While often considered a traditional and low-tech industry, construction industry is undergoing important transformation processes, driven by the introduction of new technologies, greater attention to ...
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source