Results 61 to 70 of about 173,305 (260)

Experimental and theoretical study on flexural performance of lightweight sandwich panels using FRP connectors

Case Studies in Construction Materials
Prefabricated concrete sandwich panels are crucial components in the construction of prefabricated buildings, providing essential functions such as load-bearing capacity, thermal insulation, and fire resistance.
Nengming CHENG, Juntian TANG, Peng FENG, Zhihao HAO, Yaolin ZHANG, Mingyuan CHANG   +5 more
doaj   +1 more source

RETRACTED: Obtaining chromogenic structured yarns from a mixture of carbon and polyester fibers [PDF]

E3S Web of Conferences
See the retraction notice E3S Web of Conferences 538, 00001 (2024), https://doi.org/10.1051/e3sconf ...
Parpiyev Khabibulla, Kayumov Juramirza, Zhu Guocheng, Gafurov Adkhamjon, Izatillaev Muzaffarkhon   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Simulation practice of construction engineering projects in science and technology universities: a case study of renovation of old buildings

Frontiers in Education
Cultivating high-quality applied talents who meet the requirements of the times’ development is the development direction of China's higher education strategy.
Tiantian Chen, Jiangcheng Yan, Decai Tang   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Comprehensive evaluation of low-temperature properties of PPA/CR/SBS composite modified asphalt binder and its mixtures

Results in Engineering
Asphalt pavement in cold regions often suffer from serious cracking issues, which will greatly shorten its service life. Composite modification employing polyphosphoric acid (PPA), crumb rubber (CR), and styrene-butadiene-styrene block copolymer (SBS ...
Fucheng Guo, Ning Li, Songbai Lin, Bo Li, Zhenzheng Liu, Yongning Wang, Sheng Guo, Jing Zhao, Wenzhou Li   +8 more
doaj   +1 more source

Construction industry: Priority Sector Report

, 2019
The construction industry plays a strategic role in the EU economy, accounting for 9% of gross domestic product (GDP) and 18 million direct jobs. While often considered a traditional and low-tech industry, construction industry is undergoing important transformation processes, driven by the introduction of new technologies, greater attention to ...
openaire   +2 more sources

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source