Results 71 to 80 of about 5,734,746 (248)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

BENEFITS DERIVED BY DISTRICT ASSEMBLIES FROM THEIR PROJECT CONSULTANTS

Journal of Construction Project Management and Innovation, 2013
Many of the problems in construction at the local level can be traced to consultants who supervise projects on behalf of local government agencies. Consultants therefore need to be evaluated regularly to ensure that they are delivering the expected ...
J Ayarkwa, B.K. Baiden, D. Osei-Asibey, C.B.S Sabah   +3 more
doaj   +1 more source

Analysis of the use of e-procurement in the public and private sectors of the UK construction industry [PDF]

, 2011
Summary: Eadie et.al (2010a, 2010b) identified 20 advantages in the adoption of e-procurement within a construction organisation. The Glover report (2008) indicated that by the end of 2010 all public sector procurement should be electronic.
Eadie, Robert, Perera, Srinath (R18622), Perera, Srinath, Heaney, George   +3 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Multi-dimensional analysis of the mechanism of the effects of rejuvenator and warm mixing agents on aged SBS modified asphalt

Cleaner Materials
The microstructure of warm mix recycled asphalt and the interactions among its components play a crucial role in determining its rheological properties. This study investigates the effects of aging, rejuvenators, and warm mix agents on the resistance to ...
Hui Dou, Bo Li, Ning Li, Duoneng Zhao, Fucheng Guo, Yongning Wang, Guanghuai Li   +6 more
doaj   +1 more source

Micro- structure and rheological properties of graphene oxide rubber asphalt

Nanotechnology Reviews, 2019
Compared with traditional materials, nanomaterial has rich and excellent performance due to the size advantages. If nanotechnology is combined with pavement materials, it is foreseeable that it will have a profound impact on the development of the road ...
Lin Mei, Wang Zhao Li, Yang Ping Wen, Li Ping   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preparation and performance evaluation of non-sticky wheel emulsified asphalt

Scientific Reports
To address the issue of traditional emulsified asphalt easily adhering to wheels during construction, thereby causing interlayer bonding failure, a novel non-stick wheel emulsified asphalt was developed using 30# base asphalt as the raw material.
Jia Wang, Changyu Pu, Huabao Ma, Chao Sun   +3 more
doaj   +1 more source