Results 31 to 40 of about 344,688 (293)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Seismic Response Analysis of Jointed Rock Slope under Pulse-Like Ground Motions

open access: yesAdvances in Civil Engineering
Because of the forward directivity effects, energy concentration, and fling step effect of pulse-like ground motions, it is easy to cause landslide of jointed rock slope.
Xijun Jia, Yu Zhang, Ziyi Zhang
doaj   +1 more source

Multi-year maintenance planning framework using multi-attribute utility theory and genetic algorithms

open access: yesEuropean Transport Research Review, 2020
This paper introduces a comprehensive framework for the development of optimal multi-year maintenance plans for a large number of bridges. A maintenance plan is said to be optimal when, within the given budget, a maximum number of bridges can be ...
Zaharah Allah Bukhsh   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Assessment of Factors Causing Construction Delays in Building Construction Projects in Somaliland

open access: yesAdvances in Civil Engineering
Construction delays (CDs) pose persistent challenges in building projects, leading to budget and schedule overruns. This study aimed to investigate the root causes of CD in Somaliland, and ranks the factors based on significance.
Abdisalam Yusuf Duale   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Modeling Cost-Estimation Factors for Public Building Projects with Hybrid Approach in Addis Ababa

open access: yesAdvances in Civil Engineering
Assessing the most important cost-influencing factors is essential for enhancing the predictive ability of cost estimation for building construction projects.
Behailu Temesgen Habe   +2 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Analysis of construction dynamic plan using fuzzy critical path method [PDF]

open access: yesTehnika, 2014
Critical Path Method (CPM) technique has become widely recognized as valuable tool for the planning and scheduling large construction projects. The aim of this paper is to present an analytical method for finding the Critical Path in the precedence ...
Kurij Kazimir V.   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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