Results 91 to 100 of about 3,082,738 (358)

Ceramic thermal protective coating withstands hostile environment of rotating turbine blades [PDF]

, 1975
Ceramic coatings have low thermal conductivity. They provide potential for increased engine performance, reduced fuel consumption, use of less costly materials or construction procedures, and increased life and ...
Liebert, C. H., Stecura, S.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Spontaneous hierarchical surface engineering of minerals through coupled dissolution‐precipitation chemistry

Aggregate
Peculiar hierarchical microstructures in creatures inspire modern material design with distinct functionalities. Creatures can effortlessly construct sophisticated yet long‐range ordered microstructure across bio‐membrane through ion secretion and ...
Jinyang Jiang, Jiawen Zhang, Lanxin Wang, Zeyu Lu, Fengjuan Wang, Zhiyong Liu, Hongbo Zeng   +6 more
doaj   +1 more source

Superhydrophobic SiO2/Trimethylchlorosilane Coating for Self-Cleaning Application of Construction Materials [PDF]

, 2022
Aliya Kurbanova, Nurbala Myrzakhmetova, Nazgul Akimbayeva, K. O. Kishibayev, Marzhan Nurbekova, Yernar Kanagat, Arailym Tursynova, Tomiris Zhunussova, Aidar Seralin, Rabiga Kudaibergenova, Zhexenbek Toktarbay, Olzat Toktarbaiuly   +11 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

In-situ resource utilization in the design of advanced lunar facilities [PDF]

Resource utilization will play an important role in the establishment and support of a permanently manned lunar base. At the University of Houston - College of Architecture and the Sasakawa International Center for Space Architecture, a study team ...

core   +1 more source

High temperature circuit breaker [PDF]

, 1970
Alternating current circuit breaker is suitable for reliable long-term service at 1000 deg F in the vacuum conditions of outer space. Construction materials are resistant to nuclear radiation and vacuum welding.
Edwards, R. N., Travis, E. F.
core   +1 more source

Finding a third archetypal technical system in architectural phenomenology [PDF]

, 2009
Within the scope of phenomenology and in order to understand architecture, the role of the technical system is as important as those of the purpose of the building or its form.
Balan, Simona A, Blum, Arlene, Cousins, Ian T, de Voogt, Pim, Diamond, Miriam, Fletcher, Tony, Goldenman, Gretta, Higgins, Christopher, Lindeman, Avery E, Peaslee, Graham, Scheringer, Martin, Trier, Xenia, Wang, Zhanyun, Weber, Roland   +13 more
core   +4 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Multi-Scale Numerical Simulation on Thermal Conductivity of Bio-Based Construction Materials [PDF]

, 2022
Gang Huang, Ariane Abou‐Chakra, Sandrine Geoffroy, Joseph Absi   +3 more
openalex   +1 more source