Results 101 to 110 of about 3,079,502 (307)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Developments in the Built EnvironmentTimber construction offers significant environmental advantages, and the recent rise of timber buildings, culminating in record-setting high-rises, demonstrates a growing trend toward tall timber structures.
Haoze Chen, Libo Yan, Junaid Ajaz Dand
doaj +1 more source
Quarrying and Sustainability during Urbanazion: Gebze District Case [PDF]
The requirement of construction materials increases along with the developing urbanization. Despite the most of quarries are established in rural or semi rural areas, their locations remain in or close to the urban areas in parallel with the expansion of
Ertan Mert, Zeynep Gamze Mert
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Graphite ionization vacuum gauge [PDF]
, 1974 Triode gauge with electron source, electron collector, and positive ion collector made from either graphite or carbon material extends low-pressure ranges of existing gauges by changing only materials used in construction.
Beitel, G. A., Benson, D. K.
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Current Market Landscape and Industry Voices in Key Timber Construction Markets
BuildingsThe global timber construction market is experiencing steady growth, driven by increasing demand for sustainable building solutions, advancements in engineered timber technologies, and supportive policy frameworks.
Libo Yan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Research Report on a Study of Non-Modular Masonry Construction [PDF]
, 1949 In 1947, the Small Homes Council made a detailed study and comparison of construction methods used in residential building. Included in this study was an analysis of three houses in wich modular brick were used in the exterior cavity-type masonry wall ...
Lendrum, James T., Rettberg, G.C.
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
High temperature circuit breaker [PDF]
, 1970 Alternating current circuit breaker is suitable for reliable long-term service at 1000 deg F in the vacuum conditions of outer space. Construction materials are resistant to nuclear radiation and vacuum welding.
Edwards, R. N., Travis, E. F.
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