Results 61 to 70 of about 3,082,738 (358)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Case Studies in Construction MaterialsThis study investigates the effects of steel fiber shape (straight and hooked-end) and content (0, 0.5, 1.0, and 1.5 vol%) on rheological properties, printability, mechanical performance and microstructure of 3D printable steel fiber reinforced high ...
Zijian Jia +7 more
doaj +1 more source
Carbon footprint generated by the main materials used in the construction of educational institutions in the Northern Sierra of Peru [PDF]
, 2022 Wilter Javier Vásquez Mejía +2 more
openalex +1 more source
Brick and Concrete Masonry [PDF]
, 1960 Describes the various materials used in brick and concrete masonry construction: some of the more common masonry systems, and the details that go into making rna onry walls strong durable and weather ...
Brotherson, Donald E.
core
Efficient construction of linear models in materials modeling and applications to force constant expansions [PDF]
, 2020 Linear models, such as force constant (FC) and cluster expansions, play a key role in physics and materials science. While they can in principle be parametrized using regression and feature selection approaches, the convergence behavior of these ...
Erhart, Paul +2 more
core +2 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Integrating continuous mineral-impregnated carbon fibers into digital fabrication with concrete
Materials & DesignDigital concrete technologies, such as 3D concrete printing, have the potential to be game changers in the construction industry by reducing material consumption and offering a high level of automation.
Tobias Neef +2 more
doaj +1 more source
Analysis of timber as sustainable material for construction [PDF]
, 2014 Comunicació presentada a IN-TECH 2014 International Conference on Innovative Technologies (Leiria, Portugal 10-13, september 2014).Facing the climate change scenario, professionals and technicians of civil engineering and architecture are searching for ...
Braulio-Gonzalo, Marta +2 more
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