Results 111 to 120 of about 5,489,361 (292)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Desvios de custos e prazos em empreendimentos da construção civil: categorização e fatores de influência

Ambiente Construído
Desvios de custos e prazos são desafios recorrentes na construção civil. Neste artigo, os autores objetivaram revisar sistematicamente a literatura relacionada a desvios de prazos e custos para determinar uma estrutura de categorização e respectivos ...
Elisa Atália Daniel Muianga, Ariovaldo Denis Granja, Joyce de Andrade Ruiz   +2 more
doaj   +1 more source

Construction time, cost and testing data of a prefabricated isolation medical unit for COVID-19. [PDF]

Data Brief, 2020
Zhou Y, Zhang Z, Wang B, Ren G, Qi H, Wang X.   +5 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Forecasting Total and Type-Specific Non-Residential Building Construction Spending: The Case Study of the United States and Lessons Learned

Buildings
Forecasting construction spending is important for civil engineering practitioners to make business decisions. Currently, the main body of forecasting literature pertains exclusively to aggregate construction investment, such as total construction ...
Xingrui Zhang, Yunpeng Wang, Shuai Xu, Eunhwa Yang, Lingxiao Meng   +4 more
doaj   +1 more source

Construction of N-body time-symmetric initial data sets in general relativity

, 2009
Given a collection of N asymptotically Euclidean ends with zero scalar curvature, we construct a Riemannian manifold with zero scalar curvature and one asymptotically Euclidean end, whose boundary has a neighborhood isometric to the disjoint union of a ...
Chruściel, Piotr T., Corvino, Justin, Isenberg, James   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Broad-area-search of new construction using time series analysis of Landsat and Sentinel-2 data

Science of Remote Sensing
New construction activities can alter surface albedo and structure, which then affect surface temperature and roughness, and hence have a significant impact on urban climate.
Xiaojing Tang, Madison G. Barrett, Kangjoon Cho, Kelsee H. Bratley, Katelyn Tarrio, Yingtong Zhang, Hanfeng Gu, Peter Rasmussen, Marc Bosch, Curtis E. Woodcock   +9 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Construction in Italy's regions, 1861-1913 [PDF]

This paper presents time-series estimates of construction activity in the regions of post-Unification Italy. Total construction followed very different time paths, reflecting the sharply local cycles in railway construction.
Ciccarelli, Carlo, Fenoaltea, Stefano
core   +1 more source