Results 161 to 170 of about 48,291 (214)

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li   +8 more
wiley   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

open access: yesAdvanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu   +12 more
wiley   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

open access: yesAdvanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang   +5 more
wiley   +1 more source

The critical need to accelerate cerebral palsy research with consumer engagement, global networks, and adaptive designs. [PDF]

open access: yesJ Pediatr Rehabil Med
Thomas SP   +7 more
europepmc   +1 more source

Drop‐Location‐Insensitive Droplet‐Based Electricity Generator Using Polydimethylsiloxane Slippery Covalently Attached Liquid Coatings

open access: yesAdvanced Science, EarlyView.
Drop‐location sensitivity remains a key barrier to practical droplet‐based electricity generators (DEGs). Here, a polydimethylsiloxane slippery covalently attached liquid (PDMS‐SCAL)‐coated interface promotes droplet sliding instead of splitting or bouncing, allowing stable electricity generation from randomly falling raindrops. The resulting PDMS‐SCAL‐
Jung Bin Yang   +6 more
wiley   +1 more source

Synergistic Additive and Bulky Cation Engineering via a Sequential Vacuum Dry‐Dipping Process for Tin Perovskite Solar Cells

open access: yesAdvanced Science, EarlyView.
A spin‐coating‐free sequential blade–dipping process is developed for efficient tin perovskite solar cells. Amorphous SnI2 templates are blade‐coated and vacuum‐dried, followed by a vertical dipping conversion. Enhanced by a synergistic additive matrix and bifunctional BATo cation, the resulting devices achieve a benchmark power conversion efficiency ...
Chun‐Hsiao Kuan   +13 more
wiley   +1 more source

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