Results 31 to 40 of about 885,634 (311)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

COMPARATIVE STUDY OF “KLIM-TEST” MONOCLONAL ANTIBODIES FOR PHENOTYPING OF PERIPHERAL BLOOD CELLS WITH MONOCLONALS FROM FOREIGN PRODUCERS

Медицинская иммунология, 2014
In view of wide-spread usage of flow cytometry (FC) in various areas of modern medicine, Russian market is still dominated by foreign manufacturers of monoclonal antibodies (MAbs).
A. A. Popova, L. V. Serebrovskaya, L. A. Ivanova, O. N. Khokhlova, S. N. Novozhilov   +4 more
doaj   +1 more source

Results of modern radiation-hygienic surveys of settlements of Bryansk Oblast of the Russian Federation bordering the Republic of Belarus. Part 1: Characteristics of the settlements

Радиационная гигиена, 2023
This study presents results of radiation-hygienic surveys of the Bryansk Oblast settlements bordering the Republic of Belarus. The data were obtained in the course of implementation of measures of the “Program of joint activities of Russia and Belarus ...
I. K. Romanovich, A. B. Bazyukin, A. N. Barkovsk, A. M. Biblin, A. A. Bratilova, G. Ya. Bruk, K. V. Varfolomeev, A. V. Gromov, E. A. Drozdova, T. V. Zhesko, S. A. Ivanov, M. V. Kaduka, T. A. Kormanovskaya, O. S. Kravtsova, V. A. Nekrasov, V. P. Ramzaev, K. A. Saprykin, N. V. Titov, O. A. Isakov, E. I. Zlotnikova, A. G. Sosnitskiy, V. I. Filin, A. V. Kudryashov, A. A. Ladik, V. A. Lalayan   +24 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Use of Molecular Genetic Methods for Investigation of Outbreaks of Enterovirus Infection in the Subjects of the Far Eastern Federal District

Эпидемиология и вакцинопрофилактика, 2016
The results of molecular genetic studies of clinical samples taken from three foci of outbreaks of enterovirus infection, registered on the territory of Khabarovsk Krai and Amur Oblast from 2012 through 2013 were reported.
L. V. Butakova, O. E. Trotsenko, E. Yu. Sapega, V. O. Kotova, L. A. Balakhontseva, T. A. Zaitseva, O. P. Kurganova   +6 more
doaj   +1 more source

“Volunteering” to Arbitrate Through Predispute Arbitration Clauses: The Average Consumer’s Experience [PDF]

, 2004
This article helps build the empirical foundation necessary for an informed debate regarding arbitration clauses in consumer contracts by providing preliminary insight into how businesses\u27 use of these clauses affects consumers\u27 ability to pursue ...
Demaine, Linda J., Hensler, Deborah R.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Prevalence of ARVI, influenza, and COVID-19 pathogens in individuals without symptoms of respiratory infection

Журнал микробиологии, эпидемиологии и иммунобиологии, 2021
Introduction. SARS-CoV-2 can be transmitted by infected people without or with mild symptoms of acute respira-tory infection (ARI). Monitoring based on nucleic acid amplification techniques is used to measure the prevalence of ARI pathogens and to assess
S. B. Yatsyshina, M. V. Mamoshina, M. A. Elkina, G. V. Sharukho, Yu. I. Raspopova, А. Ya. Folmer, K. A. Agapov, I. M. Vladimirov, O. V. Zubareva, I. S. Novikova, O. B. Bondareva, V. A. Gil, D. N. Kozlovskikh, S. V. Romanov, O. V. Dikonskaya, A. V. Ponomareva, I. V. Chistyakova, N. I. Kochneva, A. I. Yurovskikh, E. P. Kadnikova, A. S. Kilyachina, S. V. Luchinina, R. R. Kosareva, G. G. Chirkova, N. N. Valeullina, L. A. Lebedeva, T. N. Detkovskaya, E. I. Abbasova, O. B. Romanova, E. V. Pyatyrova, V. G. Akimkin   +30 more
doaj   +1 more source