Results 71 to 80 of about 88,973 (257)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Prioritised review of the existing maximum residue levels for dimethoate and omethoate according to Article 43 of Regulation (EC) No 396/2005

EFSA Journal, 2016
In compliance with Article 43 of Regulation (EC) No 396/2005, EFSA received from the European Commission a mandate to conduct a prioritised review of the existing maximum residue levels (MRL) for dimethoate and omethoate, as a follow up of its ‘statement
European Food Safety Authority (EFSA)
doaj   +1 more source

Identification of the risks of consumer credit cooperatives

Вестник университета, 2019
Various types of classification of risks of credit consumer cooperatives have been considered. The author’s approach to the classification of cooperative risks based on the account of losses associated with risk situations has been adduced.
V. Yu Didenko, N. I. Morozko, N. I. Morozko   +2 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Review of Quantitative Microbial Risk Assessment in Poultry Meat: The Central Position of Consumer Behavior [PDF]

, 2020
Tahreem Khalid, Ammar Hdaifeh, Michel Fédérighi, Enda Cummins, Géraldine Boué, Sandrine Guillou, Vincent Tesson   +6 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neurocognitive impairments identified through neuropsychological assessments.
Jeong‐Won Jeong, Min‐Hee Lee, Hiroshi Uda, Yoon Ho Hwang, Michael Behen, Aimee Luat, Csaba Juhász, Eishi Asano   +7 more
wiley   +1 more source

Electrochemical Detection of Bisphenol S Based on Molecularly Imprinted Polymers Grafted on Functionalized Multiwalled Carbon Nanotubes: A Facile Sensor Fabrication Approach

Chemosensors
Bisphenol S (BPS), a key ingredient in polycarbonate plastics and epoxy resins, is a known endocrine-disrupting compound that poses significant risks to human health and the environment.
Christopher Mwanza, Lin Zhao, Qing Zhang, Shou-Nian Ding   +3 more
doaj   +1 more source

Revision of the review of the existing maximum residue levels for thiabendazole

EFSA Journal, 2016
In compliance with Article 43 of Regulation (EC) No 396/2005, EFSA received from the European Commission a mandate to update its previous review of the existing maximum residue levels (MRLs) for thiabendazole on the basis of the new toxicological ...
European Food Safety Authority (EFSA)
doaj   +1 more source