Results 71 to 80 of about 1,638,525 (392)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Multilayered hollow transition metal nitride spheres made from single-source precursors for SERS analytics

Nature Communications
Traditional high-temperature and high-pressure synthesis routes make transition metal nitride (TMN) grains prone to sintering and agglomeration, thus synthesis of architectures with high specific surface area and pore volume is an urgent problem to be ...
Xiaoyu Song, Yahui Li, Meng Yin, Junfang Li, Haifeng Yang, Wei Liu, Xiaotian Wang, Guangcheng Xi   +7 more
doaj   +1 more source

Non-targeted analysis of odor components and hazardous volatiles in children's raincoats

Ecotoxicology and Environmental Safety
Given the widespread use of children's raincoats and their close contact with children and students, it is crucial to identify the odor components and potential chemical hazards associated with these products. In this study, 128 volatiles were identified
Haoyang Shi, Shuang Liang, Zhijuan Wang, Qing Lv, Qing Zhang, Meiping Li   +5 more
doaj   +1 more source

Feel Safe to Take More Risks? Insecure Attachment Increases Consumer Risk-Taking Behavior [PDF]

, 2019
open access ...
Jiang, Feng, Lan, Junmei, Li, Yuan Yuan, Lu, Su   +3 more
core   +3 more sources

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Review of the existing maximum residue levels for fluopyram according to Article 12 of Regulation (EC) No 396/2005

EFSA Journal, 2020
According to Article 12 of Regulation (EC) No 396/2005, EFSA has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance fluopyram.
European Food Safety Authority (EFSA), Maria Anastassiadou, Giovanni Bernasconi, Alba Brancato, Luis Carrasco Cabrera, Luna Greco, Samira Jarrah, Aija Kazocina, Renata Leuschner, Jose Oriol Magrans, Ileana Miron, Stefanie Nave, Ragnor Pedersen, Hermine Reich, Alejandro Rojas, Angela Sacchi, Miguel Santos, Alois Stanek, Anne Theobald, Benedicte Vagenende, Alessia Verani   +20 more
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Assessing the health risks of consuming ‘sachet’ alcohol in Acoli, Uganda

PLOS ONE, 2019
The increased mortality rate among the Acoli people of northern Uganda is anecdotally blamed on excessive consumption of cheap and widely available sachet-packaged alcohol in the region. In this paper, we quantify this perceived association by determining statistically the health risks associated with ingesting 20 heavy metals in 17 popular spirits ...
Ochan Otim, Tom Juma, Olara Otunnu
openaire   +7 more sources

Occurrence of cyclic imines in European commercial seafood and consumers risk assessment [PDF]

Environmental Research, 2018
Cyclic imines constitute a quite recently discovered group of marine biotoxins that act on neural receptors and that bioaccumulate in seafood. They are grouped together due to the imino group functioning as their common pharmacore, responsible for acute neurotoxicity in mice.
Rambla-Alegre, Maria, Miles, Christopher O., de la Iglesia, Pablo, Fernandez-Tejedor, Margarita, Jacobs, Silke, Sioen, Isabelle, Verbeke, Wim, Samdal, Ingunn A., Sandvik, Morten, Barbosa, Vera, Tediosi, Alice, Madorran, Eneko, Granby, Kit, Kotterman, Michiel, Calis, Tanja, Diogene, Jorge   +15 more
openaire   +7 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source