Results 81 to 90 of about 3,193,008 (366)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Double dividend : promoting good nutrition and sustainable consumption through healthy school meals

, 2012
This report, produced by the Sustainable Consumption Roundtable tackles the issues surrounding promoting good nutrition and sustainable consumption through healthy school meals.Publisher ...
Soil Association, Green, Michael, Morgan, Kevin, Sonnino, Roberta, Pearce, Hannah, Noble, Emma, Sustainable Consumption Roundtable (Great Britain)   +6 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Consumption and (in) Appropriate Use of Mobile Phone Among Teenage Africans in the UK

, 2008
Black Africans constitute a small proportion of previous audience research into mobile consumption. Most especially, the teenage Africans, who are most likely than adult Africans to adopt mobile phones, are under researched despite their increasing ...
Brayford Pool, Gratifications Consumption   +1 more
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Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Understanding the underlying systems dynamics contributing to the continued predominance of the unhealthy motorway food environment in the Netherlands: identifying leverage points and actions for change

BMC Medicine
Background Motorway food environments are dominated by roadside restaurants and petrol station stores offering predominantly unhealthy quick-service meals and foods for on-the-go consumption.
Lisanne Geboers, Coosje Dijkstra, Frédérique C. Rongen, Sanne K. Djojosoeparto, Maartje P. Poelman   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Systems thinking for local food environments: a participatory approach identifying leverage points and actions for healthy and sustainable transformations

Health Research Policy and Systems
Background Current local food environments encourage poor diets, posing a significant threat to public and planetary health. Acknowledging and addressing its inherent complexity is vital to making meaningful improvements to the food environment.
Tamika M. Wopereis, Coosje Dijkstra, Joline J. Wierda, Frédérique C. Rongen, Maartje P. Poelman   +4 more
doaj   +1 more source

More than the worksite cafeteria: the workplace food environment of small and medium-sized enterprises in the Netherlands

Public Health Nutrition
Objective: To characterise the food environment of Dutch small and medium-sized enterprises (SMEs), encompassing physical, sociocultural, economic and policy features and to explore variations within SMEs according to company characteristics (number of ...
Lisanne Geboers, Emely de Vet, Frédérique C Rongen, Maartje P Poelman   +3 more
doaj   +1 more source

Sustainable Consumption Roundtable : response to ‘Taking it on’ consultation

, 2012
This contribution to the Government’s ‘Taking It On’ consultation is from the Sustainable Consumption Roundtable (SCR), a joint initiative between the Sustainable Development Commission and the National Consumer Council.Publisher ...
Sustainable Consumption Roundtable (Great Britain)
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