Results 51 to 60 of about 305,802 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Consumption of Cultural Content in the Digital Environment in the Post-Pandemic Latvia

Economics and Culture, 2023
Research purpose. COVID-19 has a huge impact on the life-style in modern society, including the switching to online studies and remote work. The majority of the studies view the consequences as negative, while at the same time the pandemic have enhanced ...
Budanceva Jelena, Svirina Anna
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Mídia, consumo e crime na juventude: a construção de um traçado teórico

Caderno CRH
Refletir sobre o consumo na modernidade abre caminho para pensar a possibilidade de surgimento de ações criminosas como meio de acesso a bens, ofertando a alguns indivíduos a chave de entrada a grupos sociais dos quais somente é possível pertencer ...
Patricia Bandeira de Melo, Rodrigo Vieira de Assis   +1 more
doaj   +1 more source

Kültür Endüstrisi, Tüketim ve Narsizm

İdrak Dini Araştırmalar Dergisi, 2021
Adorno nesneler çağını yaşadığımızdan bahseder. Nesneler hayatımıza o kadar müdahil olmuştur ki artık insan yaşayışına nesnelerin ritmi, hız kesmeksizin hayatımıza dahil oluş serüveni yön vermektedir.
Halil İbrahim Özasma
doaj  

Tüketim, Tüketim Toplumu ve Tüketim Kültürü: Karşılaştırmalı Bir Analiz / Consumption, Consumption Society and Consumption Culture: A Comparative Analysis [PDF]

İnsan&İnsan Bilim Kültür Sanat ve Düşünce Dergisi, 2017
Bu makale, tüketim, tüketim toplumu ve tüketim kültürü kavramlarına odaklanmak¬tadır. Bu kavramların literatürde nasıl tanımlandığına değinerek, karşılaştırmalı bir analizi¬ni sunmayı amaçlamaktadır.
Olkan SENEMOĞLU
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Culture of Consumption

, 2003
An encyclopedia piece 
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source