Results 81 to 90 of about 11,053,629 (293)

Effect of Altered OCT Image Quality on Deep Learning Boundary Segmentation

IEEE Access, 2020
Deep learning methods provide a platform to segment boundaries within the retina and choroid in OCT images of the posterior eye, with the ultimate goal of having a robust model that works well across a wide range of different datasets.
Jason Kugelman, David Alonso-Caneiro, Scott A. Read, Stephen J. Vincent, Fred K. Chen, Michael J. Collins   +5 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Barriers, motivators and enablers for dispensing multifocal contact lenses in Mumbai, India

Journal of Optometry, 2015
Purpose: To understand the potential barriers, motivators and enablers in dispensing multifocal contact lenses (MFCL). Method: Two focus group discussions were conducted to design questionnaires regarding the prescribing habits for multifocal contact ...
Nilesh Thite, Ukti Shah, Jasmin Mehta, Janice Jurkus   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Tribological Behavior of Anodized Aluminum Oxide (AAO) Under the Addition of PAO6 Lubrication with Nano-Alumina

Lubricants
Anodizing can generate porous wear-resistant layers, which can act as reservoirs for gradually releasing lubricants. Studies on the formation of zinc dialkyl dithiophosphate (ZDDP) tribofilms in non-ferrous metals are relatively rare. Furthermore, adding
Marina C. Vasco, Rodrigo L. Villanova, Giuseppe Pintaude   +2 more
doaj   +1 more source

The Use of Contact Heat Generators of the New Generation for Heat Production [PDF]

, 2016
We substantiated the need for searching for, and realization of, fundamentally new approaches, using more efficient physical, heat-mass-exchanging and aerodynamic processes, which will make it possible to improve energy effectiveness and ecological ...
Daschenko, O. (Olga), Kasyanchuk, S. (Stanyslav), Ocheretyanko, M. (Mykola), Romanova, K. (Kateryna), Varlamov, G. (Gennadii)   +4 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

A DEFIANT AND CRITICAL FEMALE VOICE IN THE EIGHTEENTH CENTURY: MARY HAYS AND THE “MEMOIRS OF EMMA COURTNEY”

Studia Universitatis Babeş-Bolyai. Philologia, 2017
A Defiant and Critical Female Voice in the Eighteenth Century: Mary Hays and the Memoirs of Emma Courtney. Mary Hays was heavily engaged in examining the position of woman in the patriarchal society of the Age of Enlightenment.
Hakan YILMAZ
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source