Results 91 to 100 of about 3,784,270 (306)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Nonlinear dynamic behaviors of angular contact ball bearing with waviness based on a synthetical multi-degree-of-freedom mathematical modelling

Journal of Low Frequency Noise, Vibration and Active Control
This paper proposes a synthetical multi-degree-of-freedom mathematical modelling for analyzing the dynamic characteristics of angular contact ball bearing with waviness subjected to the external load working conditions.
Zhen Li, Qingshan Wang, Ruihua Wang, Bin Qin, Wen Shao   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Gold coated carbon nanotube surfaces as low force electrical contacts for MEMS devices: part 1

, 2009
An experimental investigation of a gold coated vertically aligned carbon nanotube surfaces is undertaken to determine the limits of the electrical contact performance over a large number of switching cycles under low force conditions and with current ...
Yunus, E.M., Spearing, S.M., McBride, J.W.   +2 more
core   +1 more source

A study on the contact condition and the collision behaviour of a wheelset with a flat set on a roller rig

Nihon Kikai Gakkai ronbunshu, 2018
To investigate and understand conditions of mutual contact and collision impact between a wheel-flat and a roller rig, we first did a bench test of a bogie with the wheel flat on the roller rig.
Yasutaka MAKI, Yoshiaki TERUMICHI
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Intermittent‐Contact Heterodyne Force Microscopy [PDF]

Journal of Nanomaterials, 2009
Heterodyne Force Microscopy opens up a way to monitor nanoscale events with high temporal sensitivity from the quasistatic cantilever mechanical‐diode response taking advantage of the beat effect. Here, a novel heterodyne ultrasonic force method is proposed, in which the cantilever is driven in amplitude‐modulation mode, at its fundamental flexural ...
openaire   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source