Results 81 to 90 of about 3,784,270 (306)
Multimodal microscopy using 'half and half' contact mode and ultrasonic force microscopy [PDF]
Advances in the design and fabrication of multifunctional nanostructured materials require characterization techniques capable of simultaneously mapping multiple material properties with nanoscale resolution.
Wilson, Neil R. +6 more
core +1 more source
Contact dynamics from the atomic scale to nanostructured surfaces [PDF]
, 2007 The collective mechanical behavior of a multitude of small contacts affects the friction between sliding bodies on the macroscopic scale. The contacts are complicated systems involving many atoms, which are constantly deformed, ruptured and reformed.
Maier, Sabine
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2014 Appropriate relation among the inertia, suspension characteristics and brake force distribution will be required for achieving comfortable motion of vehicle and stable contact forces at braking. At a forethought stage where the design concept is decided,
Ryoichi KURASAKO +2 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Carbon nanotube surfaces for low force contact application
, 2009 This thesis focuses on developing a testing method to estimate the mechanical and electrical characteristics of CNT-based contact surfaces. In particular the use of gold thin films deposited on a CNT forest has potential to offer a very effective contact
Yunus, Pg Hj Md Esa Al-Islam bin Pg Hj Md
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
, 2008 Gold coated vertically aligned multi-walled carbon-nanotubes (Au/MWCNT) surfaces are investigated to determine the electrical contact performance under low force conditions with repeated load cycling.
Yunus, E.M. +2 more
core +1 more source