Results 71 to 80 of about 1,174,398 (306)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
An asperity-based finite element model for electrical contact of microswitches [PDF]
, 2013 Precise prediction of electrical contact resistance is important for microswitches. The contact spot used to beconsidered as a circle in earlier literature, where there was only one geometrical parameter: the radius of the a-spots.
Colin, Stephane +7 more
core +1 more source
Simulation Study of Stochastic Wind Field of Catenaries with Spatial Correlativity
机车电传动, 2010 According to catenary construction, at unreduced precision, a multivariable simulation model of catenary stochastic pulsation wind field based on the harmonic synthesis was proposed, which properly simplifies wind speed coherence function and power ...
曹树森, 秦剑, 柯坚, 刘晓红
doaj
Contact Line Dynamics and Droplet Spreading
FluidsContact line motion occurs when a liquid encounters a solid surface [...]
Alireza Mohammad Karim
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Forced spreading over superhydrophobic and copper surfaces
EPJ Web of Conferences, 2017 Dynamic spreading over superhydrophobic and copper surfaces was studied experimentally under the condition of contact line movement with speed greater than 1 mm/sec.
Feoktistov Dmitry +2 more
doaj +1 more source
Nihon Kikai Gakkai ronbunshu, 2014 The dynamic contact angle, the angle between the surfaces of the liquid and the solid at a moving contact line, is one of the primary conditions for the dynamics of the liquid surface confined by solid wall.
Takahiro ITO +6 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source