Results 121 to 130 of about 14,225,696 (298)

Electroosmotic reinforcement mechanism and laboratory tests of pulsating direct current with a high energy efficiency ratio

Soils and Foundations
Based on the electroosmotic reinforcement mechanism of pulsating direct current (PDC) with a high energy efficiency ratio, the calculation method of PDC electroosmosis drainage rate was verified under different potential gradients using two forms of ...
Xunli Zhang, Lingwei Zheng, Shangqi Ge, Xudong Zheng, Xinyu Xie   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Ismaili Contact (Europe) Silver Jubilee [PDF]

, 1982
Ismaili Contact (Europe) Silver Jubilee - Salegreh 1982https://ecommons.aku.edu/arch_research_publications_secondary-sources/1033/thumbnail ...
Ismaili Contact,
core   +1 more source

FRACTAL STRUCTURE OF MULTI-ELEMENT COATINGS

Eurasian Physical Technical Journal, 2018
The paper shows that the surface layer of a metal is a nanostructure. This surface layer possesses nonlinear properties that depend on its size and all physical properties. The phenomenon of electron emission from a metal under the action of an external
S.A. Guchenko, O.N. Zavatskaya, V.M. Yurov, S.S. Kasymov, V.Ch. Laurinas   +4 more
doaj  

Achieving Ultra‐Low Contact Resistance via Copper‐Intercalated Bilayer MoS2

Advanced Electronic Materials
The high contact resistance between MoS2 and metals hinders its potential as an ideal solution for overcoming the short‐channel effect in silicon‐based FETs at sub‐3 nm scales.
Huan Wang, Xiaojie Liu, Hui Wang, Yin Wang, Haitao Yin   +4 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Static Stability Analysis of Planar Grasps by Multiple Fingers with Redundant Joints

Actuators
This paper deals with static stability in planar grasps of an object by multiple fingers. Differently from previous research, we focus on the case that each finger has redundant links and joints.
Takayoshi Yamada
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source