Results 51 to 60 of about 2,623,768 (284)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Stress concentration in periodically rough hertzian contact: Hertz to soft-flat-punch transition
, 2016 We report on the elastic contact between a spherical lens and a patterned substrate, composed of an hexagonal lattice of cylindrical pillars. The stress field and the size of the contact area are obtained by means of numerical methods (discrete Green's ...
Ledesma-Alonso, Rene +4 more
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Modelling a Coupled Thermoelectromechanical Behaviour of Contact Elements via Fractal Surfaces [PDF]
, 2016 A three-dimensional coupled thermoelectromechanical model for electrical connectors is here proposed to evaluate local stress and temperature distributions around the contact area of electric connectors under different applied loads.
GUARNIERI, MASSIMO +2 more
core +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Atomic size oscillations in conductance histograms for gold nanowires and the influence of work hardening [PDF]
, 2005 Nanowires of different nature have been shown to self-assemble as a function of stress at the contact between two macroscopic metallic leads. Here we demonstrate for gold wires that the balance between various metastable nanowire configurations is ...
Csonka, Sz. +6 more
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Contact Analysis of EMB Actuator Considering Assembly Errors with Varied Braking Intensities
VehiclesDifferential planetary roller lead screw (DPRS) serves as a quintessential actuating mechanism within the electromechanical braking (EMB) systems of vehicles, where its operational reliability is paramount to ensuring braking safety.
Xinyao Dong +5 more
doaj +1 more source
Stress Wave Anisotropy in Centered Square Highly Nonlinear Granular Systems [PDF]
, 2012 Highly ordered, close packed granular systems present a nonlinear dynamic behavior stemming from the Hertzian contact interaction between particles. We investigated the propagation of elastic stress waves in an uncompressed, centered square array of ...
Daraio, C., Leonard, A.
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source