Results 71 to 80 of about 5,023,948 (237)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Contact Analysis and Structural Improvement of the Swivel Joints in High Pressure Manifold
Shiyou jixie, 2018 During the operation of the swivel joint in the oilfield, pitting and obvious indentation of the ball bearing at the joint were observed and affected its operation.
Guo Dengming, Wang Sui, Bian Heman
doaj
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Reducing the Diameter of Freight Vehicle Wheels – The Suitability of Q/D as a Control for Wheel-Rail Contact Stress [PDF]
, 2013 High wheel-rail contact stress is related to rail damage mechanisms such as gross plastic flow. Such high contact stresses are often generated by freight vehicles which have comparatively high axleloads.
Osman, Martin +3 more
core +3 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Effects of Tooth Slotting on Mechanical Properties of Filtering Reducer
工程科学与技术, 2014 :The influence of slotting on the mechanical properties and transmission performance of gear teeth of filtering gear reducers was studied through finite element method.According to the comparative results of different slot shapes,it is found that ...
王家序 +5 more
doaj
Optimal Design of Spur Gears With Increased Contact Ratio
Journal of Mechanical EngineeringThe study is devoted to optimal design of gears with profile contact ratio εα ≥ 2. Optimality criteria formulated as follows: the contact stresses in the pitch point must take a minimum value when all constraints are met, first, when the profile contact ...
Ustynenko Oleksandr +6 more
doaj +1 more source
Contact Characteristics of Active Elbow in High-Pressure Manifold
Shiyou jixie, 2022 In order to investigate the raceway pitting corrosion of the active elbow in high-pressure manifold in oil and gas fields,a large-diameter active elbow of Model 130.2 mm-105 MPa(5 1/8 in-15 000 psi)was taken as an example to investigate the influences of
Zhang Guoyou
doaj
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source