Results 71 to 80 of about 670,771 (266)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Optimal Design of Spur Gears With Increased Contact Ratio
Journal of Mechanical EngineeringThe study is devoted to optimal design of gears with profile contact ratio εα ≥ 2. Optimality criteria formulated as follows: the contact stresses in the pitch point must take a minimum value when all constraints are met, first, when the profile contact ...
Ustynenko Oleksandr +6 more
doaj +1 more source
Contact Characteristics of Active Elbow in High-Pressure Manifold
Shiyou jixie, 2022 In order to investigate the raceway pitting corrosion of the active elbow in high-pressure manifold in oil and gas fields,a large-diameter active elbow of Model 130.2 mm-105 MPa(5 1/8 in-15 000 psi)was taken as an example to investigate the influences of
Zhang Guoyou
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Analysis of Sealing Performance of Special Gas Seal Thread of Downhole Safety Valve
Shiyou jixie, 2022 Downhole safety valve, as a necessary safety device, is widely used in the development of high-sulfur gas fields and offshore oil and gas fields. The thread sealing performance is one of the important elements in the research and development of downhole ...
Wang Chuanhong +5 more
doaj
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Study on Contact Characteristics of Cold Rolled Deformation Zone of Ultra-High-Strength Steel
MetalsThis study investigates the longitudinal deformation behavior of ultra-high-strength steel (UHSS) during the cold rolling process. First, rolling experiments were conducted on UHSS, and longitudinal surface coordinates of the deformation zone were ...
Jianhui Wang +5 more
doaj +1 more source
Factors that impact the patellofemoral contact stress in the TKA: a review. [PDF]
Arthroplasty, 2023 Yu Z, Cai H, Liu Z.
europepmc +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Study on Contact Stress Distribution Characteristics and Damage of Plug Seedlings Based on Flexible Pressure Sensor. [PDF]
Sensors (Basel), 2023 Cui J, Li X, Zeng F, Bai H.
europepmc +1 more source