Results 71 to 80 of about 669,241 (267)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Analysis of Sealing Performance of Special Gas Seal Thread of Downhole Safety Valve

Shiyou jixie, 2022
Downhole safety valve, as a necessary safety device, is widely used in the development of high-sulfur gas fields and offshore oil and gas fields. The thread sealing performance is one of the important elements in the research and development of downhole ...
Wang Chuanhong, Yan Biao, Zhou Xin, Zou Gang, Yang Xiaocheng, Sun Qiaolei   +5 more
doaj  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Effects of Tooth Slotting on Mechanical Properties of Filtering Reducer

工程科学与技术, 2014
:The influence of slotting on the mechanical properties and transmission performance of gear teeth of filtering gear reducers was studied through finite element method.According to the comparative results of different slot shapes,it is found that ...
王家序, 汪正炜, 蒲伟, 周广武, 何涛, 张渝爽   +5 more
doaj  

Study on Contact Characteristics of Cold Rolled Deformation Zone of Ultra-High-Strength Steel

Metals
This study investigates the longitudinal deformation behavior of ultra-high-strength steel (UHSS) during the cold rolling process. First, rolling experiments were conducted on UHSS, and longitudinal surface coordinates of the deformation zone were ...
Jianhui Wang, Zhenhua Bai, Yuan Gao, Zhourun Shi, Zifei Guo, Xuetong Li   +5 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Factors that impact the patellofemoral contact stress in the TKA: a review. [PDF]

Arthroplasty, 2023
Yu Z, Cai H, Liu Z.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Study on Contact Stress Distribution Characteristics and Damage of Plug Seedlings Based on Flexible Pressure Sensor. [PDF]

Sensors (Basel), 2023
Cui J, Li X, Zeng F, Bai H.
europepmc   +1 more source