Results 81 to 90 of about 2,651,640 (305)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Design of straight bevel gear for pitting resistance [PDF]
FME Transactions, 2018 Based on the Tredgold geometric approximation, a transparent contact stress capacity model for straight bevel gears is presented. A bevel load factor is defined which provides a kinetic link between the physical bevel gear and virtual spur gear.
Osakue Edward E., Lucky Anetor
doaj
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Stress concentration in the vicinity of a hole defect under conditions of Hertzian contact [PDF]
Two dimensional photoelastic stress analyses were conducted for epoxy resin models containing a hole defect under the conditions of Hertzian contact. Stress concentrations around the defect were determined as a function of several parameters.
Eguchi, M., Murayama, K., Yamamoto, T.
core +1 more source
, 2012 A method to couple interparticle contact models with Stokesian dynamics (SD) is introduced to simulate colloidal aggregates under flow conditions.
A.A. Potanin +47 more
core +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Evaluation of contact stress distribution on the surface of tibial insert component: Finite element analysis [PDF]
Songklanakarin Journal of Science and Technology (SJST)The purpose of this study was to evaluate and compare the contact stress distributions on the surface of the tibial insert between the posterior-stabilized (PS) and cruciate-retaining (CR) total knee arthroplasty (TKA).
Techin Seechaipat +2 more
doaj
Reducing the Diameter of Freight Vehicle Wheels – The Suitability of Q/D as a Control for Wheel-Rail Contact Stress [PDF]
, 2013 High wheel-rail contact stress is related to rail damage mechanisms such as gross plastic flow. Such high contact stresses are often generated by freight vehicles which have comparatively high axleloads.
Eickhoff, Bridget +3 more
core
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source