Results 11 to 20 of about 1,605,312 (259)

Blocking domain 6 of high molecular weight kininogen to understand intrinsic clotting mechanisms

Research and Practice in Thrombosis and Haemostasis, 2022
Background The contact system is initiated by factor (F) XII activation and the assembly of high molecular weight kininogen (HK) with either FXI or prekallikrein (PK) on a negatively charged surface.
Pradeep K. Singh, Zu‐Lin Chen, Katharina Horn, Erin H. Norris   +3 more
doaj   +1 more source

Antithrombotics and new interventions for venous thromboembolism: Exploring possibilities beyond factor IIa and factor Xa inhibition

Research and Practice in Thrombosis and Haemostasis, 2021
Direct oral anti–activated factor X and antithrombin agents have largely replaced vitamin K antagonists as the standard of care in treatment of venous thromboembolism.
Anna C. Mavromanoli, Stefano Barco, Stavros V. Konstantinides   +2 more
doaj   +1 more source

The impact of puberty on the onset, frequency, location, and severity of attacks in hereditary angioedema due to C1-inhibitor deficiency: A survey from the Italian Network for Hereditary and Acquired Angioedema (ITACA)

Frontiers in Pediatrics, 2023
IntroductionHereditary angioedema due to C1-inhibitor deficiency is influenced by hormonal factors, with a more severe course of disease in women. Our study aims to deepen the impact of puberty on onset, frequency, location and severity of attacks ...
Mauro Cancian, Paola Triggianese, Stella Modica, Francesco Arcoleo, Donatella Bignardi, Luisa Brussino, Caterina Colangelo, Ester Di Agosta, Davide Firinu, Maria Domenica Guarino, Francesco Giardino, Marica Giliberti, Vincenzo Montinaro, Riccardo Senter   +13 more
doaj   +1 more source

Contact and near-contact binary systems - X. The contact system TV Muscae [PDF]

Monthly Notices of the Royal Astronomical Society, 1989
Les observations spectroscopique et photometrique de la binaire TV Muscae du type W UMa sont presentees. L'analyse des parametres physiques montre que ce systeme est en contact etroit (f=0.13±0.05) et possede un rapport de masse extreme de 0.135±0 ...
R. W. Hilditch, D. J. King, T. M. McFarlane   +2 more
openaire   +1 more source

Factor XII-Driven Inflammatory Reactions with Implications for Anaphylaxis

Frontiers in Immunology, 2017
Anaphylaxis is a life-threatening allergic reaction. It is triggered by the release of pro-inflammatory cytokines and mediators from mast cells and basophils in response to immunologic or non-immunologic mechanisms.
Lysann Bender, Henri Weidmann, Stefan Rose-John, Thomas Renné, Thomas Renné, Andy T. Long   +5 more
doaj   +1 more source

The contact activation system and vascular factors as alternative targets for Alzheimer's disease therapy

Research and Practice in Thrombosis and Haemostasis, 2021
Alzheimer's disease (AD) is the most common neurodegenerative disease, affecting millions of people worldwide. Extracellular beta‐amyloid (Aβ) plaques and neurofibrillary tau tangles are classical hallmarks of AD pathology and thus are the prime targets ...
Pradeep K. Singh, Ana Badimon, Zu‐Lin Chen, Sidney Strickland, Erin H. Norris   +4 more
doaj   +1 more source

Deletion of the L-Lactate Dehydrogenase Gene ldh in Streptococcus pyogenes Leads to a Loss of SpeB Activity and a Hypovirulent Phenotype

Frontiers in Microbiology, 2017
Streptococcus pyogenes uses lactic acid fermentation for the generation of ATP. Here, we analyzed the impact of a deletion of the L-lactate dehydrogenase gene ldh on the virulence of S. pyogenes M49. While the ldh deletion does not cause a general growth
Sonja Oehmcke-Hecht, Leif E. Nass, Jan B. Wichura, Stefan Mikkat, Bernd Kreikemeyer, Tomas Fiedler   +5 more
doaj   +1 more source

Coagulation and complement: Key innate defense participants in a seamless web

Frontiers in Immunology, 2022
In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is activated and complement is regulated, wrote, “In the study of biological processes, the accumulation of information is often accelerated by a narrow point of ...
Edward L. G. Pryzdial, Edward L. G. Pryzdial, Edward L. G. Pryzdial, Alexander Leatherdale, Alexander Leatherdale, Edward M. Conway, Edward M. Conway, Edward M. Conway, Edward M. Conway   +8 more
doaj   +1 more source

Isolated nonequilibrium systems in contact [PDF]

Physical Review E, 2007
4 pages, 3 ...
Shokef, Yair, Shulkind, Gal, Levine, Dov
openaire   +3 more sources

The Search for Biomarkers in Hereditary Angioedema

Frontiers in Medicine, 2017
The unpredictable nature of attacks of tissue swelling in hereditary angioedema requires the identification of reliable biomarkers to monitor disease activity as well as response to therapy.
Allen P. Kaplan, Coen Maas
doaj   +1 more source