Results 51 to 60 of about 1,097 (257)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Prompt-Driven and Kubernetes Error Report-Aware Container Orchestration

Future Internet
Background: Container orchestration systems like Kubernetes rely heavily on declarative manifest files, which serve as orchestration blueprints.
Niklas Beuter, André Drews, Nane Kratzke   +2 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Mixed-Runtime Pod Networking for Kubernetes-Based Edge Computing

IEEE Access
In recent years, microservice-based applications have shifted towards cloud-edge computing, taking advantage of green energy, lower latencies, and local computational resources.
Tom Goethals, Miel Verkerken, Merlijn Sebrechts, Filip De Turck, Bruno Volckaert   +4 more
doaj   +1 more source

CONTAINER ORCHESTRATION WITH KUBERNETES

Journal of Artificial Intelligence, Machine Learning and Data Science
The research paper focuses on the effectiveness of Kubernetes in container orchestration. In this concern, it investigates the sports industry to assess the way Kubernetes can support this industry for its operational management. This system can be combined with Azure cloud and ML algorithms for better resource allocation and schedule management.
openaire   +2 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Analisis Perbandingan Kinerja Container Network Interface Flannel dan Cilium sebagai Interface Utama pada Multus CNI dalam Jaringan Klaster Kubernetes

Journal of Internet and Software Engineering
Container menjadi alternatif virtualisasi infrastruktur layanan internet berkat efisiensi penggunaan sumber daya. Infrastruktur IT dapat terdiri dari beragam container, dengan Kubernetes berperan sebagai Container Orchestration.
Bayu Agung Prakoso, Unan Yusmaniar Oktiawati   +1 more
doaj   +1 more source

Refining Microservices Placement Employing Workload Profiling Over Multiple Kubernetes Clusters

IEEE Access, 2020
As cloud-native computing is becoming the de-facto paradigm in the cloud field, Microservices Architecture has attracted attention from industries and researchers for agility and efficiency. Moreover, with the popularity of the IoT in the context of edge
Jungsu Han, Yujin Hong, Jongwon Kim
doaj   +1 more source