Results 71 to 80 of about 150,874 (288)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Analisis Perbandingan Kinerja Container Network Interface Flannel dan Cilium sebagai Interface Utama pada Multus CNI dalam Jaringan Klaster Kubernetes

Journal of Internet and Software Engineering
Container menjadi alternatif virtualisasi infrastruktur layanan internet berkat efisiensi penggunaan sumber daya. Infrastruktur IT dapat terdiri dari beragam container, dengan Kubernetes berperan sebagai Container Orchestration.
Bayu Agung Prakoso, Unan Yusmaniar Oktiawati   +1 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Container Orchestration with Kubernetes for ROS-Based Robot Software

Applied Sciences
Robot Operating System (ROS) applications are growing increasingly complex and distributed, incorporating multi-node architectures, real-time communication, and compute offloading to cloud or edge resources.
Nicholas Hopf, Rafael Arrais, Pedro Melo, Armando Sousa, David José Castro, Pedro Estela   +5 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

DACCA: Distributed Adaptive Cloud Continuum Architecture

Future Internet
Recently, the need for unified orchestration frameworks that can manage extremely heterogeneous, distributed, and resource-constrained environments has emerged due to the rapid development of cloud, edge, and IoT computing.
Nektarios Deligiannakis, Vassilis Papataxiarhis, Michalis Loukeris, Stathes Hadjiefthymiades, Marios Touloupou, Syed Mafooq Ul Hassan, Herodotos Herodotou, Thanasis Moustakas, Emmanouil Bampis, Konstantinos Ioannidis, Iakovos T. Michailidis, Stefanos Vrochidis, Elias Kosmatopoulos, Francisco Javier Romero Martínez, Rafael Marín Pérez, Amr Mousa, Jacopo Castellini, Pablo Strasser   +17 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Security Challenges and Solutions in Kubernetes Container Orchestration

, 2022
This study aims to uncover vulnerabilities, provide practical mitigation measures, and highlight policy implications by examining the security issues and solutions associated with Kubernetes container orchestration.
Princess Egbuna, Oluebube
core  

KubAnomaly: Anomaly detection for the Docker orchestration platform with neural network approaches

Engineering Reports, 2019
Kubernetes, which is the most popular orchestration platform for Docker containers, is used widely for developing microservices and automating Docker instance life cycle administration.
Chin‐Wei Tien, Tse‐Yung Huang, Chia‐Wei Tien, Ting‐Chun Huang, Sy‐Yen Kuo   +4 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source